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GHR
Description
growth hormone receptor
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Cytoplasmic Ribonucleoprotein Granule
Receptor Complex
Growth Hormone Receptor Complex
Molecular Function
Cytokine Receptor Activity
Growth Hormone Receptor Activity
Protein Binding
Peptide Hormone Binding
Growth Factor Binding
Protein Kinase Binding
Cytokine Binding
Identical Protein Binding
Protein Homodimerization Activity
Proline-rich Region Binding
Biological Process
Activation Of MAPK Activity
Endocytosis
Receptor Signaling Pathway Via JAK-STAT
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Cellular Response To Hormone Stimulus
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Hormone Metabolic Process
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Activation Of Janus Kinase Activity
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Pathways
Prolactin receptor signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Somatotropin
Pegvisomant
Somatrem
Somapacitan
Diseases
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Blood protein levels (
30072576
29875488
)
Familial squamous cell lung carcinoma (
29924316
)
Heel bone mineral density (
30598549
)
Height (
28552196
25429064
31562340
)
Iron status biomarkers (
19084217
)
Menarche (age at onset) (
25231870
)
Plasma renin activity levels (
29650764
)
Response to taxane treatment (docetaxel) (
23006423
)
Systemic lupus erythematosus (
18204098
)
Novel Interacting Genes
1 novel interacting genes:
CLCC1
Interacting Genes
44 interacting genes:
AP2A1
BTRC
CISH
CUL1
CUL5
DUSP7
ELOB
ELOC
FBXO31
GH1
GH2
GRB10
GRB2
IRS1
JAK1
JAK2
NCOA6
NEDD8
PIK3R1
PIK3R2
PLCG1
PTPN1
PTPN11
PTPN13
PTPN2
PTPN3
PTPN6
PTPN9
PTPRB
PTPRH
RBX1
RNF7
SGTA
SHC1
SKP1
SOCS1
SOCS2
SOCS3
SRPK2
STAT3
STAT5A
STAT5B
STUB1
TYK2
Entrez ID
2690
HPRD ID
02971
Ensembl ID
ENSG00000112964
Uniprot IDs
A0A087X0H5
A0A087X162
P10912
PDB IDs
1A22
1AXI
1HWG
1HWH
1KF9
2AEW
3HHR
5OEK
5OHD
Enriched GO Terms of Interacting Partners
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