PANX1

Description		pannexin 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Bleb Protein-containing Complex
	Molecular Function	Protease Binding Signaling Receptor Binding Structural Molecule Activity Calcium Channel Activity Protein Binding Wide Pore Channel Activity Leak Channel Activity Ion Channel Binding Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding
	Biological Process	Response To Ischemia Cation Transport Calcium Ion Transport Cell-cell Signaling Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Response To ATP Oogenesis Calcium Ion Transmembrane Transport
Pathways		Electric Transmission Across Gap Junctions The NLRP3 inflammasome
Drugs		Probenecid
Diseases
GWAS		Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010) Autoimmune thyroid disease ( 32581359) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Squamous cell lung carcinoma ( 28604730)
Novel Interacting Genes		1 novel interacting genes: KEAP1
Interacting Genes		16 interacting genes: APOA2 APOL2 AQP2 BCL2L2 BUD31 CFHR5 CLCA4 FAXDC2 FDFT1 GNAS P2RX7 SLC38A7 TMEM229B TNF VAMP5 WFDC2
Entrez ID		24145
HPRD ID		10526
Ensembl ID		ENSG00000110218
Uniprot IDs		A0A024R397 Q96RD7
PDB IDs		6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN
Enriched GO Terms of Interacting Partners?
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