FCN1

Description		ficolin 1
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Extrinsic Component Of External Side Of Plasma Membrane Secretory Granule Lumen Collagen-containing Extracellular Matrix Ficolin-1-rich Granule Lumen
	Molecular Function	G Protein-coupled Receptor Binding Antigen Binding Signaling Receptor Binding Protein Binding Carbohydrate Binding Sialic Acid Binding Pattern Recognition Receptor Activity Metal Ion Binding Carbohydrate Derivative Binding
	Biological Process	Complement Activation, Lectin Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Complement Activation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Protein Localization To Cell Surface Neutrophil Degranulation Recognition Of Apoptotic Cell Negative Regulation Of Viral Entry Into Host Cell
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Trans-epidermal water loss ( 28011148)
Novel Interacting Genes		1 novel interacting genes: TSC1
Interacting Genes		2 interacting genes: ELN TGFB1
Entrez ID		2219
HPRD ID		03153
Ensembl ID		ENSG00000085265
Uniprot IDs		O00602
PDB IDs		2D39 2JHH 2JHI 2JHK 2JHL 2JHM 2WNP
Enriched GO Terms of Interacting Partners?
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