EPO

Description		erythropoietin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Cell Body
	Molecular Function	Cytokine Activity Erythropoietin Receptor Binding Hormone Activity Protein Binding Protein Kinase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Acute-phase Response Signal Transduction Embryo Implantation Aging Blood Circulation Positive Regulation Of Cell Population Proliferation Response To Salt Stress Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-serine Phosphorylation Erythrocyte Differentiation Activation Of Protein Kinase Activity Response To Lipopolysaccharide Response To Vitamin A Response To Testosterone Erythropoietin-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Hemoglobin Biosynthetic Process Erythrocyte Maturation Response To Estrogen Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Ras Protein Signal Transduction Response To Axon Injury Response To Electrical Stimulus Response To Hyperoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Hyperosmotic Response Response To Dexamethasone Negative Regulation Of Neuron Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Erythrocyte Apoptotic Process Negative Regulation Of Cation Channel Activity
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Hematocrit ( 32888494 27863252 24777453) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 24777453) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Other erythrocyte phenotypes ( 19862010) Plateletcrit ( 32888494) Pursuit maintenance gain in psychotic disorders ( 29064472) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: EP300 EPOR HIF1A
Entrez ID		2056
HPRD ID		00586
Ensembl ID		ENSG00000130427
Uniprot IDs		G9JKG7 P01588
PDB IDs		1BUY 1CN4 1EER
Enriched GO Terms of Interacting Partners?
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