AKR1C1

Description		aldo-keto reductase family 1 member C1
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Estradiol 17-beta-dehydrogenase Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Carboxylic Acid Binding Bile Acid Binding Dihydrotestosterone 17-beta-dehydrogenase Activity 17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase Activity Androsterone Dehydrogenase Activity 5alpha-androstane-3beta,17beta-diol Dehydrogenase Activity Androsterone Dehydrogenase (B-specific) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity
	Biological Process	Retinoid Metabolic Process Prostaglandin Metabolic Process Xenobiotic Metabolic Process Digestion Steroid Metabolic Process Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Intestinal Cholesterol Absorption Epithelial Cell Differentiation Progesterone Metabolic Process Retinal Metabolic Process Cholesterol Homeostasis Daunorubicin Metabolic Process Doxorubicin Metabolic Process Response To Organophosphorus Cellular Response To Jasmonic Acid Stimulus
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Retinoid metabolism and transport
Drugs		NADH Salicylic acid Acetylsalicylic acid Nicotinamide adenine dinucleotide phosphate Naringenin 2-HYDROXY-3,5-DIIODOBENZOIC ACID Epitestosterone Hexestrol
Diseases
GWAS		Blood protein levels ( 29875488) Economic and political preferences (immigration/crime) ( 22566634) Height ( 25282103) Hypopharyngeal or laryngeal cancer ( 32276964) Lung cancer ( 28604730) Metabolite levels ( 23823483) Squamous cell lung carcinoma ( 28604730)
Novel Interacting Genes		2 novel interacting genes: SUFU TNFRSF18
Interacting Genes		3 interacting genes: COMMD8 MAPK3 PTPN3
Entrez ID		1645
HPRD ID		07194
Ensembl ID		ENSG00000187134
Uniprot IDs		Q04828
PDB IDs		1MRQ 3C3U 3GUG 3NTY 4YVP 6A7A 6IJX
Enriched GO Terms of Interacting Partners?
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