CYP51A1

Description		cytochrome P450 family 51 subfamily A member 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Sterol 14-demethylase Activity Oxidoreductase Activity Heme Binding
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Sterol Metabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Protein Secretion Demethylation Negative Regulation Of Amyloid-beta Clearance
Pathways		Cholesterol biosynthesis Endogenous sterols Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Tioconazole Itraconazole Levoketoconazole (S)-econazole
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lifespan ( 25918517) Pulse pressure ( 30578418)
Novel Interacting Genes		2 novel interacting genes: GRM3 STT3B
Interacting Genes		1 interacting genes: ZNF420
Entrez ID		1595
HPRD ID		03381
Ensembl ID		ENSG00000001630
Uniprot IDs		A0A0C4DFL7 Q16850
PDB IDs		3JUS 3JUV 3LD6 4UHI 4UHL 6Q2T 6UEZ
Enriched GO Terms of Interacting Partners?
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