AMER1

Description		APC membrane recruitment protein 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Nuclear Body Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Beta-catenin Binding Beta-catenin Destruction Complex Binding
	Biological Process	Wnt Signaling Pathway Positive Regulation Of Protein Ubiquitination Bone Development Adipose Tissue Development Regulation Of Canonical Wnt Signaling Pathway Mesenchymal Cell Differentiation Involved In Kidney Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly
Pathways		Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex
Drugs
Diseases		Osteopathia striata with cranial sclerosis
GWAS
Interacting Genes		5 interacting genes: AXIN1 BTRC CTNNB1 KEAP1 SRPK2
Entrez ID		139285
HPRD ID		06565
Ensembl ID		ENSG00000184675
Uniprot IDs		Q5JTC6
PDB IDs		4YJE 4YJL 4YK6
Enriched GO Terms of Interacting Partners?
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