COL11A1

Description		collagen type XI alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type XI Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Metal Ion Binding Extracellular Matrix Binding Heparan Sulfate Binding
	Biological Process	Cartilage Condensation Ossification Chondrocyte Development Proteoglycan Metabolic Process Visual Perception Sensory Perception Of Sound Extracellular Matrix Organization Collagen Fibril Organization Endodermal Cell Differentiation Tendon Development Inner Ear Morphogenesis Embryonic Skeletal System Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Ventricular Cardiac Muscle Tissue Morphogenesis
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Non-integrin membrane-ECM interactions MET activates PTK2 signaling Collagen chain trimerization
Drugs
Diseases		Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Type XI collagenopathies, including: Stickler syndrome type 2; Stickler syndrome type 3; Otospondylomegaepiphyseal dysplasia (OSMED); Marshall syndrome; Weissenbacher-Zweymuller syndrome
GWAS		Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia ( 29266176) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carpal tunnel syndrome ( 30833571) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Femoral neck bone mineral density ( 22504420) Glaucoma (primary angle closure) ( 22922875 27064256) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Height ( 28552196) Hip bone size ( 31053729) Intelligence (MTAG) ( 29326435) Intertrochanteric region size ( 31053729) Lateral ventricle temporal horn volume ( 31530798) Open-angle glaucoma and optic cup area ( 29449654) Osteoarthritis (hip) ( 30374069) Protein quantitative trait loci ( 18464913) Spine bone size ( 31053729) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic juvenile idiopathic arthritis ( 27927641) Triglyceride levels x loop diuretics use interaction ( 31806883) Trochanter size ( 31053729) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		1 interacting genes: DDR1
Entrez ID		1301
HPRD ID		00375
Ensembl ID		ENSG00000060718
Uniprot IDs		P12107 Q59HB5
PDB IDs
Enriched GO Terms of Interacting Partners?
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