PIK3AP1

Description		phosphoinositide-3-kinase adaptor protein 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
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Diseases
GWAS		Alanine transaminase levels ( 29403010) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Orthostatic hypotension ( 24124408) Platelet reactivity in response to clopidogrel treatment ( 32472697)
Interacting Genes		8 interacting genes: BTK GRB2 ITSN1 ITSN2 NCK1 NCK2 PIK3R1 SYK
Entrez ID		118788
HPRD ID		06401
Ensembl ID		ENSG00000155629
Uniprot IDs		Q6ZUJ8 Q86YV3
PDB IDs		5FOR 6SWS
Enriched GO Terms of Interacting Partners?
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