SDCCAG8

Description		SHH signaling and ciliogenesis regulator SDCCAG8
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol Cell-cell Junction Centriolar Satellite Ciliary Basal Body Photoreceptor Cell Cilium
	Molecular Function	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Neuron Migration Centrosome Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Establishment Of Cell Polarity Microtubule Organizing Center Organization Tube Formation Ciliary Basal Body-plasma Membrane Docking Regulation Of Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163 29124443) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 28135244 27841878 30578418) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Mean platelet volume ( 32888494) Mental health study participation (completed survey) ( 31263887) Metabolite levels ( 23823483) Obesity (early onset extreme) ( 20421936) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Schizophrenia ( 25056061 29483656 30285260 23974872) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Toenail selenium levels ( 25343990)
Novel Interacting Genes		3 novel interacting genes: AKT3 CEP170 RGS7
Interacting Genes		2 interacting genes: FBXO7 TNS2
Entrez ID		10806
HPRD ID		10215
Ensembl ID		ENSG00000054282
Uniprot IDs		Q86SQ7
PDB IDs
Enriched GO Terms of Interacting Partners?
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