PPP1R16B - HiPPIP

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
ATPAF2	ATP synthase mitochondrial F1 complex assembly factor 2
CDCA7L	cell division cycle associated 7 like
CDK5RAP1	CDK5 regulatory subunit associated protein 1
CEP55	centrosomal protein 55
CEP70	centrosomal protein 70	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
CRX	cone-rod homeobox
DVL2	dishevelled segment polarity protein 2	TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
DVL3	dishevelled segment polarity protein 3	TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
FAM83A	family with sequence similarity 83 member A
FAM83D	family with sequence similarity 83 member D
FARS2	phenylalanyl-tRNA synthetase 2, mitochondrial	Mitochondrial tRNA aminoacylation	Phenylalanine
FLYWCH1	FLYWCH-type zinc finger 1
GATA1	GATA binding protein 1	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
GFAP	glial fibrillary acidic protein	Nuclear signaling by ERBB4 Chaperone Mediated Autophagy
GOLGA2	golgin A2	Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
HAPLN2	hyaluronan and proteoglycan link protein 2
IKZF3	IKAROS family zinc finger 3
KCTD9	potassium channel tetramerization domain containing 9
MAGOH	mago homolog, exon junction complex subunit	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
MCEE	methylmalonyl-CoA epimerase	Propionyl-CoA catabolism
MISP	mitotic spindle positioning
MYL9	myosin light chain 9	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
NEFL	neurofilament light chain	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
NFX1	nuclear transcription factor, X-box binding 1
PATZ1	POZ/BTB and AT hook containing zinc finger 1
PHC2	polyhomeotic homolog 2	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
PLEKHN1	pleckstrin homology domain containing N1
PPP1CA	protein phosphatase 1 catalytic subunit alpha	Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Circadian Clock	2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
PPP1CB	protein phosphatase 1 catalytic subunit beta	Triglyceride catabolism Downregulation of TGF-beta receptor signaling Regulation of PLK1 Activity at G2/M Transition Circadian Clock RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
RBPMS	RNA binding protein, mRNA processing factor
RFC5	replication factor C subunit 5	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint
SCNM1	sodium channel modifier 1
SF3B4	splicing factor 3b subunit 4	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
SHC3	SHC adaptor protein 3	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
SSR4	signal sequence receptor subunit 4	SRP-dependent cotranslational protein targeting to membrane
TACO1	translational activator of cytochrome c oxidase I	TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1
TADA2A	transcriptional adaptor 2A	HATs acetylate histones
TASOR2	transcription activation suppressor family member 2
TFIP11	tuftelin interacting protein 11	mRNA Splicing - Major Pathway
TLE5	TLE family member 5, transcriptional modulator	Repression of WNT target genes
TTI1	TELO2 interacting protein 1
TUFM	Tu translation elongation factor, mitochondrial	Mitochondrial translation elongation	Zinc Guanosine-5'-Diphosphate Zinc acetate Zinc chloride Zinc sulfate, unspecified form
TXN2	thioredoxin 2	Degradation of cysteine and homocysteine Detoxification of Reactive Oxygen Species
ZNF410	zinc finger protein 410
ZNF564	zinc finger protein 564	Generic Transcription Pathway

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