NR1I3 and FTH1

Number of citations of the paper that reports this interaction (PubMedID 15604093)
56

Data Source:
BioGRID (two hybrid)

		NR1I3	FTH1
Description		nuclear receptor subfamily 1 group I member 3	ferritin heavy chain 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton	Extracellular Region Nucleus Cytoplasm Cytosol Intracellular Ferritin Complex Autolysosome Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific Double-stranded DNA Binding	Ferroxidase Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Iron Ion Transport Cellular Iron Ion Homeostasis Intracellular Sequestering Of Iron Ion Immune Response Negative Regulation Of Cell Population Proliferation Negative Regulation Of Fibroblast Proliferation
Pathways			Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport
Drugs		Doxylamine Meclizine Loperamide Ketoconazole Atorvastatin Pheniramine Prasterone 16,17-Androstene-3-Ol Resveratrol Cholesterol Phenolphthalein 3,20-Pregnanedione Hexestrol Triclosan	Iron Dextran Iron Ferric pyrophosphate citrate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Blood metabolite levels ( 24816252)	Estradiol levels ( 22675492) Major depressive disorder x sex interaction ( 34099189) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)
Interacting Genes		19 interacting genes: CHD9 DEDD DNMT3L FTH1 HNF4A IGH MAP4 MED1 NCOA1 NCOA3 NR0B2 POU1F1 PPARGC1A PSMC4 PSMC5 RXRA SNRPD3 SNX13 SRC	43 interacting genes: ANK3 BAG4 BRD7 CD99 CDC16 CDC25A CDC42 CRMP1 CSF3R CSNK2B DAXX DLG4 ELL3 FTL FXR1 FXR2 GOLM1 GPR35 GRB2 KPNA2 LBP MAX MYL3 NR1I3 NR3C1 NR5A2 NTAQ1 OPTN PACSIN1 PCBP1 PCBP2 PIAS4 SDCBP SIRPA SOX5 SPP1 STAT1 TICAM2 TOLLIP TRAF4 UBR1 UNG YWHAE
Entrez ID		9970	2495
HPRD ID		04858	00615
Ensembl ID		ENSG00000143257	ENSG00000167996
Uniprot IDs		F1DAL4 Q14994	A0A024R525 P02794
PDB IDs		1XV9 1XVP	1FHA 2CEI 2CHI 2CIH 2CLU 2CN6 2CN7 2FHA 2IU2 2Z6M 3AJO 3AJP 3AJQ 3ERZ 3ES3 4DYX 4DYY 4DYZ 4DZ0 4OYN 4Y08 4YKH 4ZJK 5CMQ 5CMR 5GN8 5GOU 5JKK 5JKL 5JKM 5N26 5N27 5UP7 5UP8 5UP9 5VTD 5XB1 5YI5 5ZND 6B8F 6B8G 6FTV 6GSR 6H5I 6H6T 6H6U 6IPC 6IPO 6IPP 6IPQ 6J4A 6J7G 6JOB 6JPS 6KE2 6KE4 6M52 6M54 6WYF 6WYG 6WYH 6Z6U 6Z9E 6Z9F 7A6A 7A6B 7JGK 7JGL 7JGM 7JGN 7JGO 7JGP 7JGQ 7K26 7K3V 7K3W
Enriched GO Terms of Interacting Partners?
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