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CD36 and LYN
Number of citations of the paper that reports this interaction (PubMedID
1715582
)
100
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
CD36
LYN
Description
CD36 molecule
LYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Extracellular Space
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Apical Plasma Membrane
Endocytic Vesicle Membrane
Platelet Alpha Granule Membrane
Brush Border Membrane
Specific Granule Membrane
Receptor Complex
Membrane Raft
Phagocytic Vesicle
Cell Periphery
Nucleus
Cytoplasm
Mitochondrial Intermembrane Space
Lysosomal Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Adherens Junction
Postsynaptic Density
Mitochondrial Crista
Endocytic Vesicle Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Integrin Alpha2-beta1 Complex
Intracellular Membrane-bounded Organelle
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization, Intracellular Component
Molecular Function
Amyloid-beta Binding
Low-density Lipoprotein Particle Receptor Activity
Scavenger Receptor Activity
Long-chain Fatty Acid Transporter Activity
Protein Binding
High-density Lipoprotein Particle Binding
Lipid Binding
Short-chain Fatty Acid Transmembrane Transporter Activity
Low-density Lipoprotein Particle Binding
Toll-like Receptor Binding
Protein-containing Complex Binding
Transforming Growth Factor Beta Binding
Thrombospondin Receptor Activity
Lipoteichoic Acid Immune Receptor Activity
Lipoprotein Particle Binding
Oxidised Low-density Lipoprotein Particle Receptor Activity
Oleate Transmembrane Transporter Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Kinase Activity
SH3 Domain Binding
Ubiquitin Protein Ligase Binding
Gamma-tubulin Binding
Glycosphingolipid Binding
Transmembrane Transporter Binding
Ephrin Receptor Binding
Phosphoprotein Binding
Scaffold Protein Binding
Phosphorylation-dependent Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell-matrix Adhesion
Production Of Molecular Mediator Involved In Inflammatory Response
Lipid Metabolic Process
Fatty Acid Metabolic Process
Receptor-mediated Endocytosis
Phagocytosis, Recognition
Phagocytosis, Engulfment
Cell Adhesion
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Nitric Oxide Mediated Signal Transduction
Blood Coagulation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Storage
Positive Regulation Of Cell Death
Long-chain Fatty Acid Transport
Long-chain Fatty Acid Import Across Plasma Membrane
Short-chain Fatty Acid Transport
Lipid Storage
CGMP-mediated Signaling
Positive Regulation Of Blood Coagulation
Intestinal Cholesterol Absorption
Cholesterol Transport
Receptor Internalization
Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Lipid
Regulation Of Toll-like Receptor Signaling Pathway
Triglyceride Transport
Plasma Lipoprotein Particle Clearance
Low-density Lipoprotein Particle Clearance
Response To Stilbenoid
Negative Regulation Of Protein Import Into Nucleus
Lipoprotein Transport
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein-containing Complex Assembly
Apoptotic Cell Clearance
Long-chain Fatty Acid Import Into Cell
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-positive Bacterium
Intestinal Absorption
Sensory Perception Of Taste
Positive Regulation Of NF-kappaB Transcription Factor Activity
Low-density Lipoprotein Particle Mediated Signaling
Positive Regulation Of Phagocytosis, Engulfment
Positive Regulation Of Macrophage Cytokine Production
Positive Regulation Of ERK1 And ERK2 Cascade
Cholesterol Import
Response To Fatty Acid
Response To Linoleic Acid
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Hydroperoxide
Cellular Response To Diacyl Bacterial Lipopeptide
Energy Homeostasis
Regulation Of Action Potential
Positive Regulation Of Cold-induced Thermogenesis
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Oxidised Low-density Lipoprotein Particle Clearance
Amyloid-beta Clearance By Cellular Catabolic Process
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Amyloid Fibril Formation
Lipid Transport Across Blood-brain Barrier
Regulation Of Removal Of Superoxide Radicals
Positive Regulation Of Blood Microparticle Formation
B Cell Homeostasis
Regulation Of Cytokine Production
Regulation Of Protein Phosphorylation
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Fc Receptor Mediated Stimulatory Signaling Pathway
Tolerance Induction To Self Antigen
Histamine Secretion By Mast Cell
Platelet Degranulation
Negative Regulation Of Myeloid Leukocyte Differentiation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Fc Receptor Mediated Inhibitory Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Response To Sterol Depletion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Hormone
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Oligodendrocyte Development
Response To Organic Cyclic Compound
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Erythrocyte Differentiation
Positive Regulation Of Cell Migration
Negative Regulation Of B Cell Proliferation
Neuron Projection Development
T Cell Costimulation
Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Extracellular Stimulus
Response To Insulin
Regulation Of Mast Cell Activation
Regulation Of Cell Adhesion Mediated By Integrin
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Response To Amino Acid
Regulation Of Mast Cell Degranulation
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Regulation Of Erythrocyte Differentiation
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Response To Axon Injury
Negative Regulation Of Immune Response
B Cell Receptor Signaling Pathway
Regulation Of B Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Cellular Component Movement
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Oligodendrocyte Progenitor Proliferation
Negative Regulation Of Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Cellular Response To Retinoic Acid
Regulation Of Monocyte Chemotaxis
Regulation Of Platelet Aggregation
Dendritic Cell Differentiation
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways
Platelet degranulation
Cross-presentation of particulate exogenous antigens (phagosomes)
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
PPARA activates gene expression
Scavenging by Class B Receptors
Scavenging by Class B Receptors
Transcriptional regulation of white adipocyte differentiation
Intracellular metabolism of fatty acids regulates insulin secretion
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
GPVI-mediated activation cascade
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
CD22 mediated BCR regulation
Cyclin D associated events in G1
Platelet Adhesion to exposed collagen
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Dasatinib
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
Bosutinib
Ponatinib
Nintedanib
Fostamatinib
Diseases
GWAS
Aspartate aminotransferase levels (
29403010
33339817
)
Basophil count (
32888494
)
Blood protein levels (
30072576
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (multivariate) (
32602732
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
HDL cholesterol (
23726366
30275531
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Hemoglobin (
32888494
)
High density lipoprotein cholesterol levels (
29403010
33339817
)
Left ventricular mass (
19454037
)
Mean corpuscular hemoglobin concentration (
29403010
)
Mean corpuscular volume (
32888494
27863252
)
Mean platelet volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Night sleep phenotypes (
27126917
)
Platelet count (
29403010
33545615
32888494
22423221
27863252
)
Plateletcrit (
32888494
)
Red blood cell count (
32888494
27863252
)
Red cell distribution width (
32888494
28957414
)
Response to fenofibrate (
22890011
)
Granulocyte count (
27863252
)
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Platelet count (
32888494
)
Refractive error (
32231278
)
Serum thyroid-stimulating hormone levels (
24852370
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
White blood cell count (
29403010
32888494
27863252
)
Interacting Genes
19 interacting genes:
APOB
APP
CD9
CHRD
COL1A1
COL1A2
FYN
HSD11B1
ITGA2B
ITGA6
ITGB1
ITGB3
LDLR
LYN
MATK
SRC
THBS1
VLDLR
YES1
137 interacting genes:
ACTB
ADAM15
AGXT
AR
ARFGEF1
BANK1
BCAR1
BTK
CASP3
CASP7
CASP9
CBL
CBLC
CD19
CD22
CD36
CD72
CD79A
CD79B
CDK1
CDK2
CDKN1B
CHST15
CLCF1
COASY
CREBBP
CRH
CRKL
CSF1R
CSF2RA
CSF2RB
CSF3R
CSK
CSNK2B
CTLA4
DAPP1
DLG4
DOK1
DOK2
DOK3
EGFR
EPOR
ERBB3
ERBB4
EVL
FASLG
FCAR
FCER1G
FCGR2A
FCGR2B
FOLR1
GAB2
GAB3
GP6
GRIA3
HCLS1
HNRNPK
IGHA1
IL1B
IL2RB
IL7
IL7R
INPP5D
ITPR1
JAK2
KHDRBS1
KIT
KLHL41
LCP2
LIME1
MAP4K1
MAPK3
MATK
MET
MME
MS4A1
MS4A2
MUC1
NDFIP2
NEDD9
NEK7
NMT1
NPHS1
PAG1
PAK2
PDCD4
PDE4A
PDE4D
PECAM1
PIK3CG
PILRB
PLCG1
PLCG2
PNMA2
PPP1R15A
PPP1R8
PRAM1
PRKCD
PRKCQ
PRKDC
PRRG4
PTK2
PTK2B
PTPN6
PTPRC
RASA1
RGS16
RPL10
RPS6KB1
RPS6KB2
SGK3
SH2B2
SHC1
SKAP1
SKAP2
SLC4A1
SNCA
SOCS1
SPHK1
SPHK2
SRC
STAT3
SYK
TEC
TERF1
TNF
TRAT1
TRIM28
TRIM55
TRIM63
TRIP10
TRPA1
TRPV4
TYK2
UBB
UHRF2
UNC119
Entrez ID
948
4067
HPRD ID
01430
01301
Ensembl ID
ENSG00000135218
ENSG00000254087
Uniprot IDs
A4D1B1
B7Z6C3
E9PLT1
P16671
A8K379
P07948
Q6NUK7
PDB IDs
5LGD
1W1F
1WA7
3A4O
5XY1
6NMW
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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