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CD36 and LDLR
Number of citations of the paper that reports this interaction (PubMedID
9555943
)
99
Data Source:
BioGRID
(pull down)
CD36
LDLR
Description
CD36 molecule
low density lipoprotein receptor
Image
GO Annotations
Cellular Component
Extracellular Space
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Apical Plasma Membrane
Endocytic Vesicle Membrane
Platelet Alpha Granule Membrane
Brush Border Membrane
Specific Granule Membrane
Receptor Complex
Membrane Raft
Phagocytic Vesicle
Cell Periphery
Lysosome
Early Endosome
Late Endosome
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Clathrin-coated Pit
External Side Of Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Basolateral Plasma Membrane
Clathrin-coated Endocytic Vesicle Membrane
Low-density Lipoprotein Particle
Endolysosome Membrane
Somatodendritic Compartment
Receptor Complex
Apical Part Of Cell
Sorting Endosome
PCSK9-LDLR Complex
Molecular Function
Amyloid-beta Binding
Low-density Lipoprotein Particle Receptor Activity
Scavenger Receptor Activity
Long-chain Fatty Acid Transporter Activity
Protein Binding
High-density Lipoprotein Particle Binding
Lipid Binding
Short-chain Fatty Acid Transmembrane Transporter Activity
Low-density Lipoprotein Particle Binding
Toll-like Receptor Binding
Protein-containing Complex Binding
Transforming Growth Factor Beta Binding
Thrombospondin Receptor Activity
Lipoteichoic Acid Immune Receptor Activity
Lipoprotein Particle Binding
Oxidised Low-density Lipoprotein Particle Receptor Activity
Oleate Transmembrane Transporter Activity
Amyloid-beta Binding
Virus Receptor Activity
Protease Binding
Low-density Lipoprotein Particle Receptor Activity
Calcium Ion Binding
Protein Binding
Low-density Lipoprotein Particle Binding
Very-low-density Lipoprotein Particle Receptor Activity
Clathrin Heavy Chain Binding
Identical Protein Binding
Lipoprotein Particle Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell-matrix Adhesion
Production Of Molecular Mediator Involved In Inflammatory Response
Lipid Metabolic Process
Fatty Acid Metabolic Process
Receptor-mediated Endocytosis
Phagocytosis, Recognition
Phagocytosis, Engulfment
Cell Adhesion
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Nitric Oxide Mediated Signal Transduction
Blood Coagulation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Storage
Positive Regulation Of Cell Death
Long-chain Fatty Acid Transport
Long-chain Fatty Acid Import Across Plasma Membrane
Short-chain Fatty Acid Transport
Lipid Storage
CGMP-mediated Signaling
Positive Regulation Of Blood Coagulation
Intestinal Cholesterol Absorption
Cholesterol Transport
Receptor Internalization
Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Lipid
Regulation Of Toll-like Receptor Signaling Pathway
Triglyceride Transport
Plasma Lipoprotein Particle Clearance
Low-density Lipoprotein Particle Clearance
Response To Stilbenoid
Negative Regulation Of Protein Import Into Nucleus
Lipoprotein Transport
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein-containing Complex Assembly
Apoptotic Cell Clearance
Long-chain Fatty Acid Import Into Cell
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-positive Bacterium
Intestinal Absorption
Sensory Perception Of Taste
Positive Regulation Of NF-kappaB Transcription Factor Activity
Low-density Lipoprotein Particle Mediated Signaling
Positive Regulation Of Phagocytosis, Engulfment
Positive Regulation Of Macrophage Cytokine Production
Positive Regulation Of ERK1 And ERK2 Cascade
Cholesterol Import
Response To Fatty Acid
Response To Linoleic Acid
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Hydroperoxide
Cellular Response To Diacyl Bacterial Lipopeptide
Energy Homeostasis
Regulation Of Action Potential
Positive Regulation Of Cold-induced Thermogenesis
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Oxidised Low-density Lipoprotein Particle Clearance
Amyloid-beta Clearance By Cellular Catabolic Process
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Amyloid Fibril Formation
Lipid Transport Across Blood-brain Barrier
Regulation Of Removal Of Superoxide Radicals
Positive Regulation Of Blood Microparticle Formation
Lipid Metabolic Process
Endocytosis
Receptor-mediated Endocytosis
Phagocytosis
Long-term Memory
Cholesterol Metabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Triglyceride Biosynthetic Process
Regulation Of Phosphatidylcholine Catabolic Process
Phospholipid Transport
Intestinal Cholesterol Absorption
Cholesterol Transport
Plasma Lipoprotein Particle Clearance
Low-density Lipoprotein Particle Clearance
High-density Lipoprotein Particle Clearance
Lipoprotein Catabolic Process
Cholesterol Homeostasis
Viral Entry Into Host Cell
Artery Morphogenesis
Positive Regulation Of Inflammatory Response
Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Response To Caloric Restriction
Negative Regulation Of Astrocyte Activation
Cholesterol Import
Cellular Response To Fatty Acid
Cellular Response To Low-density Lipoprotein Particle Stimulus
Receptor-mediated Endocytosis Involved In Cholesterol Transport
Regulation Of Cholesterol Metabolic Process
Amyloid-beta Clearance
Amyloid-beta Clearance By Cellular Catabolic Process
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Lysosomal Protein Catabolic Process
Negative Regulation Of Amyloid Fibril Formation
Pathways
Platelet degranulation
Cross-presentation of particulate exogenous antigens (phagosomes)
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
PPARA activates gene expression
Scavenging by Class B Receptors
Scavenging by Class B Receptors
Transcriptional regulation of white adipocyte differentiation
Intracellular metabolism of fatty acids regulates insulin secretion
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Chylomicron clearance
Chylomicron clearance
LDL clearance
Retinoid metabolism and transport
Drugs
Porfimer sodium
Diseases
GWAS
Aspartate aminotransferase levels (
29403010
33339817
)
Basophil count (
32888494
)
Blood protein levels (
30072576
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (multivariate) (
32602732
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
HDL cholesterol (
23726366
30275531
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Hemoglobin (
32888494
)
High density lipoprotein cholesterol levels (
29403010
33339817
)
Left ventricular mass (
19454037
)
Mean corpuscular hemoglobin concentration (
29403010
)
Mean corpuscular volume (
32888494
27863252
)
Mean platelet volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Night sleep phenotypes (
27126917
)
Platelet count (
29403010
33545615
32888494
22423221
27863252
)
Plateletcrit (
32888494
)
Red blood cell count (
32888494
27863252
)
Red cell distribution width (
32888494
28957414
)
Response to fenofibrate (
22890011
)
Abdominal aortic aneurysm (
27899403
24046328
)
Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) (
32678081
)
Apolipoprotein A1 levels (
33730874
)
Apolipoprotein B levels (
32203549
)
C-reactive protein levels or LDL-cholesterol levels (pleiotropy) (
27286809
)
Cardiovascular disease risk factors (
21943158
)
Carotid intima media thickness (
21909108
)
Carotid plaque (
30510157
)
Cholesterol (
31902109
)
Cholesterol, total (
24097068
19060911
25961943
20686565
26582766
)
Coronary artery disease (
32469254
29212778
24262325
30104761
26343387
33020668
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Coronary artery disease or ischemic stroke (
24262325
)
Coronary artery disease or large artery stroke (
24262325
)
Coronary heart disease (
21378990
)
Cortisol levels (saliva) (
28843169
)
Disorders of lipid metabolism (
30166351
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
Ischemic stroke (
29531354
)
LDL cholesterol (
23726366
24097068
18193043
18193044
20864672
19060906
19060910
19060911
30275531
21347282
25961943
20686565
26582766
)
LDL cholesterol levels (
32203549
28334899
26690388
30698716
)
LDL cholesterol levels in current drinkers (
30698716
)
LDL cholesterol levels in HIV infection (
33109212
)
LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
LDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
LDL cholesterol levels x short total sleep time interaction (2df test) (
31719535
)
Lipid metabolism phenotypes (
22286219
19936222
)
Lipoprotein phospholipase A2 activity in cardiovascular disease (
28753643
)
Lipoprotein-associated phospholipase A2 activity and mass (
22003152
)
Low density lipoprotein cholesterol levels (
30911093
29403010
33339817
31217584
31969989
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Medication use (antithrombotic agents) (
31015401
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Medication use (salicylic acid and derivatives) (
31015401
)
Metabolite levels (
21909109
23823483
22916037
)
Metabolite levels (lipoprotein measures) (
27005778
)
Myocardial infarction (
33532862
26343387
)
Myocardial infarction (early onset) (
19198609
)
Parental lifespan (
30642433
)
Parental longevity (combined parental attained age, Martingale residuals) (
29227965
)
Peripheral artery disease (
31285632
)
Response to statins (LDL cholesterol change) (
31969989
)
Serum metabolite levels (
31636271
)
Serum metabolite levels (CMS) (
31636271
)
Stroke (
29531354
)
Total cholesterol levels (
28334899
30911093
29403010
33339817
31217584
)
Interacting Genes
19 interacting genes:
APOB
APP
CD9
CHRD
COL1A1
COL1A2
FYN
HSD11B1
ITGA2B
ITGA6
ITGB1
ITGB3
LDLR
LYN
MATK
SRC
THBS1
VLDLR
YES1
17 interacting genes:
AP1M2
APOB
APOE
CD36
CREBBP
DAB1
DAB2
HSPA5
LDLRAP1
LRPAP1
MAP4
MTIF3
MYLIP
PCSK9
PF4
SNX17
TLE5
Entrez ID
948
3949
HPRD ID
01430
06091
Ensembl ID
ENSG00000135218
ENSG00000130164
Uniprot IDs
A4D1B1
B7Z6C3
E9PLT1
P16671
A0A024R7D5
P01130
PDB IDs
5LGD
1AJJ
1D2J
1F5Y
1F8Z
1HJ7
1HZ8
1I0U
1IJQ
1LDL
1LDR
1LRX
1N7D
1XFE
2FCW
2KRI
2LGP
2M7P
2MG9
2W2M
2W2N
2W2O
2W2P
2W2Q
3BPS
3GCW
3GCX
3M0C
3P5B
3P5C
3SO6
4NE9
5OY9
5OYL
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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