ATG5 and KIAA1328

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ATG5	KIAA1328
Description		autophagy related 5	KIAA1328
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Autophagosome Cytosol Axoneme Membrane Phagocytic Vesicle Membrane Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Blood Vessel Remodeling Regulation Of Cytokine Production Involved In Immune Response C-terminal Protein Lipidation Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Response To Xenobiotic Stimulus Response To Fungus Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Autophagy Of Nucleus Negative Thymic T Cell Selection Otolith Development Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Cell Development Heart Contraction Negative Regulation Of Cell Death Protein Lipidation Involved In Autophagosome Assembly Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Positive Regulation By Symbiont Of Host Autophagy Regulation Of Cilium Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Histone H4-K16 Acetylation
Pathways		Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 27363682) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 31672989) Visceral fat ( 30942860) Youthful appearance (self-reported) ( 32339537)	Body mass index ( 28552196) Ferritin levels ( 33491795) General risk tolerance (MTAG) ( 30643258) Metabolite levels ( 23823483) Periodontal disease-related phenotype (Socransky) ( 24347629) Reaction time ( 29844566) Simvastatin-induced myopathy ( 31220337) Weight ( 28552196)
Interacting Genes		29 interacting genes: ATG10 ATG12 ATG16L1 ATG16L2 ATP23 CALCOCO2 CAPN1 CAPN2 CCDC12 CCHCR1 FADD FMR1 GRIPAP1 HOOK2 INCA1 IRGM KEAP1 KIAA1328 MAD1L1 MEOX2 OGT OPTN PSMB11 RAB33B RACK1 TECPR1 TEKT4 VCP WDFY3	30 interacting genes: AMOT ANKS1A APC ATG5 CARD9 CCDC13 CENPP CEP290 CFAP206 COPB1 DEF6 EAF1 EEF2KMT FAM161A FAM161B GOLGA1 LMO1 LNX1 MTMR9 NEK6 PICK1 PKN1 PRKAA2 SYCE1L TSG101 TSGA10 TTC23 TXLNA TXLNB ZGPAT
Entrez ID		9474	57536
HPRD ID		16051	17211
Ensembl ID		ENSG00000057663	ENSG00000150477
Uniprot IDs		A9UGY9 Q7Z3H3 Q9H1Y0	Q86T90
PDB IDs		4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW
Enriched GO Terms of Interacting Partners?
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