ATG5 and TEKT4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		ATG5	TEKT4
Description		autophagy related 5	tektin 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Autophagosome Cytosol Axoneme Membrane Phagocytic Vesicle Membrane Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Mitochondria-associated Endoplasmic Reticulum Membrane	Nucleus Microtubule Cytoskeleton Sperm Flagellum
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Blood Vessel Remodeling Regulation Of Cytokine Production Involved In Immune Response C-terminal Protein Lipidation Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Response To Xenobiotic Stimulus Response To Fungus Antigen Processing And Presentation Of Endogenous Antigen Negative Regulation Of Protein Ubiquitination Aggrephagy Negative Stranded Viral RNA Replication Vasodilation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Autophagy Of Nucleus Negative Thymic T Cell Selection Otolith Development Negative Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Cell Development Heart Contraction Negative Regulation Of Cell Death Protein Lipidation Involved In Autophagosome Assembly Positive Regulation Of Mucus Secretion Cellular Response To Nitrosative Stress Positive Regulation By Symbiont Of Host Autophagy Regulation Of Cilium Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Histone H4-K16 Acetylation	Cilium Assembly Cilium Movement Involved In Cell Motility
Pathways		Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Glucose homeostasis traits ( 25524916) Limited cutaneous systemic scleroderma ( 24387989) Monobrow ( 27182965) Multiple myeloma ( 27363682) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 24387989 31672989) Visceral fat ( 30942860) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		29 interacting genes: ATG10 ATG12 ATG16L1 ATG16L2 ATP23 CALCOCO2 CAPN1 CAPN2 CCDC12 CCHCR1 FADD FMR1 GRIPAP1 HOOK2 INCA1 IRGM KEAP1 KIAA1328 MAD1L1 MEOX2 OGT OPTN PSMB11 RAB33B RACK1 TECPR1 TEKT4 VCP WDFY3	104 interacting genes: ACBD4 AKAP8L ALAS1 AMMECR1 ANKRD55 ARID5A ATG5 BCL6 BLZF1 BORCS8-MEF2B C11orf1 C1orf109 C9orf24 CTDSP1 DDIT4L EFHC2 EYA2 FAM220A GATA1 GPSM1 GRB10 GSE1 HCK HNRNPH1 HNRNPM HOXA1 HOXB5 HOXC8 IKZF3 INCA1 KPRP KRT15 KRT18 KRT34 KRT35 KRT75 KRT86 KRTAP11-1 KRTAP13-1 KRTAP13-3 KRTAP19-1 KRTAP19-2 KRTAP19-6 KRTAP26-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LASP1 LMCD1 LNX1 MAGEA4 MIIP MORN3 MYOZ3 NANOS3 NFKBID NR5A1 PCSK5 PHF11 PKP2 PLAGL2 POLDIP3 PPP1R13B PPP1R32 PRDM14 PRDM6 PROP1 PSMA1 PTH1R RAMAC RARA RBM48 RECK RFX6 RUSC1 SCN5A SLC25A6 SMAD3 SOCS4 SPATA8 SPATC1L SPG21 SUV39H1 TADA2A TEKT1 TFAP4 TOX2 TRIB3 TRIP6 TSPAN4 UBASH3A USP2 VGLL1 ZFP90 ZIM2 ZMYND12 ZNF20 ZNF417 ZNF426 ZNF474 ZNF552 ZNF581 ZNF655 ZNF688
Entrez ID		9474	150483
HPRD ID		16051	14518
Ensembl ID		ENSG00000057663	ENSG00000163060
Uniprot IDs		A9UGY9 Q7Z3H3 Q9H1Y0	A0A384MEB7 Q8WW24
PDB IDs		4GDK 4GDL 4NAW 4TQ0 4TQ1 5D7G 5NPV 5NPW
Enriched GO Terms of Interacting Partners?
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