RASAL2 and NFKBIB

Number of citations of the paper that reports this interaction (PubMedID 14743216)
321

Data Source:
HPRD (in vitro)

		RASAL2	NFKBIB
Description		RAS protein activator like 2	NFKB inhibitor beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding	Transcription Coactivator Activity Protein Binding
	Biological Process	Signal Transduction Regulation Of GTPase Activity	Transcription, DNA-templated Signal Transduction Cytoplasmic Sequestering Of NF-kappaB Positive Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide
Pathways		Regulation of RAS by GAPs RND3 GTPase cycle RND1 GTPase cycle	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) Body mass index ( 26426971 19079260) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Immune response to smallpox vaccine (IL-6) ( 22542470) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Weight ( 19079260)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		9 interacting genes: HMGB1 MCC MEOX2 MIA2 NFKBIB TRAF1 UBC USHBP1 YWHAG	43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52
Entrez ID		9462	4793
HPRD ID		05845	07260
Ensembl ID		ENSG00000075391	ENSG00000104825
Uniprot IDs		A8K2P3 Q9UJF2	G5E9C2 Q15653
PDB IDs
Enriched GO Terms of Interacting Partners?
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