NFKBIB and POLR1E

Number of citations of the paper that reports this interaction (PubMedID 26186194)
524

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		NFKBIB	POLR1E
Description		NFKB inhibitor beta	RNA polymerase I subunit E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Fibrillar Center Nucleoplasm Nucleolus RNA Polymerase I Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding	RNA Polymerase I General Transcription Initiation Factor Binding DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding
	Biological Process	Transcription, DNA-templated Signal Transduction Cytoplasmic Sequestering Of NF-kappaB Positive Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide	RNA Polymerase I Preinitiation Complex Assembly Transcription Elongation From RNA Polymerase I Promoter Nucleolar Large RRNA Transcription By RNA Polymerase I
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Interacting Genes		43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52	10 interacting genes: KLC1 NFKBIB OGT POLR1A POLR1B POLR1C POLR1G SIRT7 TAF1C UBTF
Entrez ID		4793	64425
HPRD ID		07260	15096
Ensembl ID		ENSG00000104825	ENSG00000137054
Uniprot IDs		G5E9C2 Q15653	B4E005 Q9GZS1
PDB IDs
Enriched GO Terms of Interacting Partners?
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