ITM2A and FCGR1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ITM2A	FCGR1A
Description		integral membrane protein 2A	Fc fragment of IgG receptor Ia
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Amyloid-beta Binding Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding
	Biological Process	Plasma Cell Differentiation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process	Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways			Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis
Drugs			Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS		Birth weight ( 31043758) Graves' disease ( 23612905) Height ( 18391951) Nose size ( 27182965) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781)
Interacting Genes		7 interacting genes: CLDN7 FCGR1A FNDC9 MEOX2 SIT1 TMED9 TRIM14	30 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B
Entrez ID		9452	2209
HPRD ID		02200	00904
Ensembl ID		ENSG00000078596	ENSG00000150337
Uniprot IDs		O43736	P12314
PDB IDs			3RJD 4W4O 4X4M 4ZNE
Enriched GO Terms of Interacting Partners?
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