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FCGR1A

Description Fc fragment of IgG receptor Ia
Image
GO Annotations Cellular Component
  • Plasma Membrane
  • Integral Component Of Plasma Membrane
  • Clathrin-coated Endocytic Vesicle Membrane
  • Early Endosome Membrane
Molecular Function
  • Transmembrane Signaling Receptor Activity
  • Protein Binding
  • IgG Binding
Biological Process
  • Phagocytosis, Engulfment
  • Immune Response
  • Signal Transduction
  • Cell Surface Receptor Signaling Pathway
  • Innate Immune Response
  • Regulation Of Immune Response
  • Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways
  • Cross-presentation of soluble exogenous antigens (endosomes)
  • Cross-presentation of soluble exogenous antigens (endosomes)
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
  • FCGR activation
  • FCGR activation
  • Regulation of actin dynamics for phagocytic cup formation
  • Role of phospholipids in phagocytosis
  • Interferon gamma signaling
  • FCGR3A-mediated IL10 synthesis
Drugs
  • Cetuximab
  • Etanercept
  • Human immunoglobulin G
  • Gemtuzumab ozogamicin
  • Alemtuzumab
  • Natalizumab
  • Palivizumab
  • Daclizumab
  • Bevacizumab
  • Porfimer sodium
  • Catumaxomab
  • Sarilumab
  • Trastuzumab deruxtecan
Diseases
GWAS
Interacting Genes 30 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B
Entrez ID 2209
HPRD ID 00904
Ensembl ID ENSG00000150337
Uniprot IDs P12314
PDB IDs 3RJD 4W4O 4X4M 4ZNE
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025