ABCG2 and RNF126

Number of citations of the paper that reports this interaction (PubMedID 32645369)
3

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		ABCG2	RNF126
Description		ATP binding cassette subfamily G member 2 (Junior blood group)	ring finger protein 126
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Mitochondrial Membrane Membrane Raft External Side Of Apical Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Urate Transmembrane Transporter Activity Biotin Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Riboflavin Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Xenobiotic Transmembrane Transporter Activity	Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Organic Anion Transport Urate Transport Biotin Transport Riboflavin Transport Urate Metabolic Process Transmembrane Transport Transepithelial Transport Urate Salt Excretion Export Across Plasma Membrane Transport Across Blood-brain Barrier Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System
Pathways		Heme biosynthesis Heme degradation Abacavir transmembrane transport Iron uptake and transport	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Biricodar Avatrombopag
Diseases
GWAS		Adult body size ( 32376654) Bitter beverage consumption ( 31046077) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Cardiovascular disease risk factors ( 21943158) Coffee consumption ( 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23064961) Glomerular filtration rate ( 29403010) Gout ( 33832965 25646370 29453348 21983786 32238385 30899057 31578528 27899376 23263486) Gout (combined type) ( 32238385) Gout (normal type) ( 32238385) Gout in chronic kidney disease ( 30181573) Gout vs asymptomatic hyperuricemia ( 33832965) Gout vs. Hyperuricemia ( 31289104 29453348) Hyperuricemia ( 29453348 29124443 28776340) Kidney stones ( 31729369) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Renal function-related traits (urea) ( 22797727) Renal overload gout ( 32238385 27899376) Renal underexcretion gout ( 32238385 27899376) Response to allopurinol in gout (change in serum uric acid levels) ( 30924126) Response to statins (LDL cholesterol change) ( 22331829) Serum metabolite levels ( 33031748) Serum urate levels ( 31784582) Serum urate levels in chronic kidney disease ( 30181573) Serum uric acid levels ( 21983786 30993211 29124443 29403010 31207883 32514006 30305239 24513273 26902266) Serum uric acid levels in response to allopurinol in gout ( 25676789) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Urate levels ( 31985003 20884846 31578528 18834626 20139978 23263486) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 22229870 29558500 19503597)	Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)
Interacting Genes		1 interacting genes: RNF126	40 interacting genes: ABCG2 AICDA BAG6 CENPP CSNK2B E2F1 EGFR FXN G0S2 HMGCL MAP3K1 MDM2 MIEN1 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SNUPN TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2N UBL3 UBL4A USP15 USP2 XRCC5 XRCC6
Entrez ID		9429	55658
HPRD ID		04783	11501
Ensembl ID		ENSG00000118777	ENSG00000070423
Uniprot IDs		A1LUE4 Q9UNQ0	A0A024R206 A8K0Q1 Q9BV68
PDB IDs		5NJ3 5NJG 6ETI 6FEQ 6FFC 6HBU 6HCO 6HIJ 6HZM 6VXF 6VXH 6VXI 6VXJ	2N9O 2N9P
Enriched GO Terms of Interacting Partners?
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