ABCG2

Description		ATP binding cassette subfamily G member 2 (Junior blood group)
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Mitochondrial Membrane Membrane Raft External Side Of Apical Plasma Membrane
	Molecular Function	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Urate Transmembrane Transporter Activity Biotin Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Riboflavin Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Organic Anion Transport Urate Transport Biotin Transport Riboflavin Transport Urate Metabolic Process Transmembrane Transport Transepithelial Transport Urate Salt Excretion Export Across Plasma Membrane Transport Across Blood-brain Barrier Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier
Pathways		Heme biosynthesis Heme degradation Abacavir transmembrane transport Iron uptake and transport
Drugs		Biricodar Avatrombopag
Diseases
GWAS		Adult body size ( 32376654) Bitter beverage consumption ( 31046077) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Cardiovascular disease risk factors ( 21943158) Coffee consumption ( 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23064961) Glomerular filtration rate ( 29403010) Gout ( 33832965 25646370 29453348 21983786 32238385 30899057 31578528 27899376 23263486) Gout (combined type) ( 32238385) Gout (normal type) ( 32238385) Gout in chronic kidney disease ( 30181573) Gout vs asymptomatic hyperuricemia ( 33832965) Gout vs. Hyperuricemia ( 31289104 29453348) Hyperuricemia ( 29453348 29124443 28776340) Kidney stones ( 31729369) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lipoprotein-associated phospholipase A2 activity change in response to statin therapy ( 23118302) Renal function-related traits (urea) ( 22797727) Renal overload gout ( 32238385 27899376) Renal underexcretion gout ( 32238385 27899376) Response to allopurinol in gout (change in serum uric acid levels) ( 30924126) Response to statins (LDL cholesterol change) ( 22331829) Serum metabolite levels ( 33031748) Serum urate levels ( 31784582) Serum urate levels in chronic kidney disease ( 30181573) Serum uric acid levels ( 21983786 30993211 29124443 29403010 31207883 32514006 30305239 24513273 26902266) Serum uric acid levels in response to allopurinol in gout ( 25676789) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Tea consumption ( 31046077) Urate levels ( 31985003 20884846 31578528 18834626 20139978 23263486) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 22229870 29558500 19503597)
Interacting Genes		1 interacting genes: RNF126
Entrez ID		9429
HPRD ID		04783
Ensembl ID		ENSG00000118777
Uniprot IDs		A1LUE4 Q9UNQ0
PDB IDs		5NJ3 5NJG 6ETI 6FEQ 6FFC 6HBU 6HCO 6HIJ 6HZM 6VXF 6VXH 6VXI 6VXJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?