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LPXN and PTK2B
Number of citations of the paper that reports this interaction (PubMedID
9565592
)
28
Data Source:
HPRD
(in vivo)
LPXN
PTK2B
Description
leupaxin
protein tyrosine kinase 2 beta
Image
GO Annotations
Cellular Component
Podosome
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Nuclear Speck
Cell Projection
Perinuclear Region Of Cytoplasm
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Focal Adhesion
Cell Cortex
Postsynaptic Density
NMDA Selective Glutamate Receptor Complex
Lamellipodium
Dendrite
Growth Cone
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Neuronal Cell Body
Dendritic Spine
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Apical Dendrite
Glutamatergic Synapse
Molecular Function
Transcription Coregulator Activity
Protein Binding
Metal Ion Binding
Calmodulin-dependent Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
NMDA Glutamate Receptor Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Ubiquitin Protein Ligase Binding
3-phosphoinositide-dependent Protein Kinase Binding
Protein-containing Complex Binding
Biological Process
Regulation Of Transcription, DNA-templated
Cell Adhesion
Negative Regulation Of Cell Adhesion
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cell Adhesion Mediated By Integrin
Substrate Adhesion-dependent Cell Spreading
Endothelial Cell Migration
Negative Regulation Of B Cell Receptor Signaling Pathway
Protein-containing Complex Assembly
MAPK Cascade
Oocyte Maturation
Response To Hypoxia
Positive Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Adaptive Immune Response
Marginal Zone B Cell Differentiation
Protein Phosphorylation
Apoptotic Process
Cellular Defense Response
Response To Osmotic Stress
Signal Transduction
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Hormone
Response To Glucose
Response To Lithium Ion
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Muscle Cell Apoptotic Process
Regulation Of CGMP-mediated Signaling
Regulation Of Macrophage Chemotaxis
Positive Regulation Of Neuron Projection Development
Glial Cell Proliferation
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Negative Regulation Of Bone Mineralization
Positive Regulation Of Actin Filament Polymerization
Neuron Projection Development
Regulation Of Inositol Trisphosphate Biosynthetic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Ionotropic Glutamate Receptor Signaling Pathway
Response To Immobilization Stress
Peptidyl-tyrosine Autophosphorylation
Response To Cocaine
Response To Hydrogen Peroxide
Activation Of Janus Kinase Activity
Negative Regulation Of Apoptotic Process
Stress Fiber Assembly
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of JUN Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Bone Resorption
Response To Ethanol
Negative Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Focal Adhesion Assembly
Regulation Of Synaptic Plasticity
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Calcium-mediated Signaling
Positive Regulation Of Nitric-oxide Synthase Activity
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Response To CAMP
Response To Calcium Ion
Positive Regulation Of Synaptic Transmission, Glutamatergic
Long-term Synaptic Potentiation
Long-term Synaptic Depression
Protein-containing Complex Assembly
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Fluid Shear Stress
Endothelin Receptor Signaling Pathway
Activation Of GTPase Activity
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Establishment Of Cell Polarity
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of NMDA Receptor Activity
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of B Cell Chemotaxis
Positive Regulation Of DNA Biosynthetic Process
Pathways
Signal regulatory protein family interactions
VEGFA-VEGFR2 Pathway
RHOU GTPase cycle
Interleukin-2 signaling
Drugs
Leflunomide
Genistein
4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Baricitinib
Fostamatinib
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Lymphoma (
23349640
)
Pulse pressure (
30578418
)
Ulcerative colitis (
28067908
)
Adult body size (
32376654
)
Alzheimer's disease (
31473137
)
Alzheimer's disease (late onset) (
30617256
24162737
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bone mineral content (
31790847
)
Bone mineral density (
31790847
)
Crohn's disease (
26192919
)
Dental caries (
23259602
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Family history of Alzheimer's disease (
30617256
)
Inflammatory bowel disease (
26192919
)
Monocyte count (
32888494
)
Schizophrenia (
29483656
)
Takayasu arteritis (
33308445
25604533
30498034
)
White blood cell count (
32888494
)
Interacting Genes
33 interacting genes:
AGXT
AQP1
GIT1
HDAC6
HOXA1
HOXC9
IKBKG
IMP3
ITGA4
LIMS1
LMO1
LMO3
MAP2K7
MAPK6
NDN
NR3C1
PHF21A
PLEKHH2
PLEKHN1
PLSCR4
POM121
PTK2
PTK2B
PTPN12
RNF214
RUNX1T1
SFI1
TGFB1
TNS2
TXLNB
VCL
ZNF175
ZNF426
69 interacting genes:
ARHGAP21
ARHGAP5
ASAP1
ASAP2
BCAR1
CBL
CCR5
CRK
DLG3
DLG4
DLGAP3
EFS
EGFR
ERBB2
ERBB3
EWSR1
FGFR2
FGFR3
FLT1
FYN
GNA13
GRB2
GRIN2A
GSN
IL7R
ITGB2
ITGB3
JAK1
JAK2
JAK3
KCNA2
LCK
LPXN
LYN
MAP3K4
MAPT
MATK
MCAM
MYH2
NEDD9
NPHP1
PDCD6IP
PDPK1
PIK3R1
PITPNM1
PITPNM2
PITPNM3
PRKCD
PTK2
PTPN11
PTPN12
PTPN6
PXN
RASA1
RB1CC1
SH2D3C
SHC1
SKAP2
SLC2A1
SNCA
SORBS2
SRC
STAP1
STAT3
SYK
TGFB1I1
TLN1
VAV1
ZAP70
Entrez ID
9404
2185
HPRD ID
05651
03131
Ensembl ID
ENSG00000110031
ENSG00000120899
Uniprot IDs
B7Z5P7
O60711
Q14289
PDB IDs
1X3H
4XEF
4XEK
4XEV
2FO6
2LK4
3CC6
3ET7
3FZO
3FZP
3FZR
3FZS
3FZT
3GM1
3GM2
3GM3
3H3C
3U3F
4EKU
4H1J
4H1M
4R32
4XEF
4XEK
4XEV
5TO8
5TOB
6LF3
Enriched GO Terms of Interacting Partners
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