LPXN and PLEKHH2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LPXN	PLEKHH2
Description		leupaxin	pleckstrin homology, MyTH4 and FERM domain containing H2
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body Lamellipodium Cortical Actin Cytoskeleton
	Molecular Function	Transcription Coregulator Activity Protein Binding Metal Ion Binding	Actin Binding Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Negative Regulation Of B Cell Receptor Signaling Pathway Protein-containing Complex Assembly	Negative Regulation Of Actin Filament Depolymerization
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		33 interacting genes: AGXT AQP1 GIT1 HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 LMO3 MAP2K7 MAPK6 NDN NR3C1 PHF21A PLEKHH2 PLEKHN1 PLSCR4 POM121 PTK2 PTK2B PTPN12 RNF214 RUNX1T1 SFI1 TGFB1 TNS2 TXLNB VCL ZNF175 ZNF426	2 interacting genes: LPXN PXN
Entrez ID		9404	130271
HPRD ID		05651	15149
Ensembl ID		ENSG00000110031	ENSG00000152527
Uniprot IDs		B7Z5P7 O60711	Q8IVE3
PDB IDs		1X3H 4XEF 4XEK 4XEV
Enriched GO Terms of Interacting Partners?
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