TPTE2 and PTK7

Number of citations of the paper that reports this interaction (PubMedID 28065597)
37

Data Source:
BioGRID (two hybrid)

		TPTE2	PTK7
Description		transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	protein tyrosine kinase 7 (inactive)
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Membrane Cell Projection	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity	Protein Kinase Activity Protein Binding ATP Binding Cell Adhesion Molecule Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Negative Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Signaling Dephosphorylation Peptidyl-tyrosine Dephosphorylation Phosphatidylinositol Dephosphorylation Cell Motility Regulation Of Protein Kinase B Signaling	Establishment Of Planar Polarity Kidney Development Ventricular Septum Development Axis Elongation Protein Phosphorylation Cell Adhesion Signal Transduction Positive Regulation Of Neuron Projection Development Cell Migration Actin Cytoskeleton Reorganization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Convergent Extension Lung-associated Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Synthesis of PIPs at the Golgi membrane
Drugs
Diseases
GWAS		Liver fibrosis (total hepatic collagen content) ( 32953199)	Coronary artery disease ( 29212778)
Interacting Genes		5 interacting genes: AATK BRCA1 EPHA2 LMTK2 PTK7	48 interacting genes: BYSL CDC14A CDKN1A CLIC5 CLNK CTDSP2 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 ENPP5 ERBB2 ILKAP KRTAP1-3 KRTAP10-8 MDFI MTMR1 MTMR10 MTMR6 MTMR9 MTUS2 NBPF19 NOTCH2NLA PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PSMB9 PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR RPS2 RTN4R STYX TNFRSF21 TPTE TPTE2 TRAM2 VGLL1
Entrez ID		93492	5754
HPRD ID		06003	03534
Ensembl ID		ENSG00000132958	ENSG00000112655
Uniprot IDs		Q6XPS3	Q13308
PDB IDs			6VG3
Enriched GO Terms of Interacting Partners?
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