KLF4 and USP10

Number of citations of the paper that reports this interaction (PubMedID 31748695)
14

Data Source:
BioGRID (imaging technique, enzymatic study)

		KLF4	USP10
Description		Kruppel like factor 4	ubiquitin specific peptidase 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleoplasm Transcription Regulator Complex Cytoplasm	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Protein-containing Complex Intermediate Filament Cytoskeleton
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Phosphatidylinositol 3-kinase Regulator Activity Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Transmembrane Transporter Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Defense Response To Tumor Cell Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Fate Determination Negative Regulation Of Cell Population Proliferation Epidermal Cell Differentiation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Muscle Hyperplasia Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Post-embryonic Camera-type Eye Development Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Post-embryonic Hemopoiesis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Axon Regeneration Epidermis Morphogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Telomerase Activity Canonical Wnt Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Cycloheximide Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Blastocyst Development Cellular Response To Peptide Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Core Promoter Binding Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Ubiquitin-dependent Protein Catabolic Process Autophagy Cellular Response To DNA Damage Stimulus Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1
Pathways		Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of pluripotent stem cells FOXO-mediated transcription of cell cycle genes	Termination of translesion DNA synthesis Ub-specific processing proteases
Drugs
Diseases
GWAS		Breast cancer ( 21263130) Colorectal or endometrial cancer ( 26621817) Coronary artery disease ( 33020668) Cotinine glucuronidation ( 25293881) Cutaneous malignant melanoma ( 26237428) Glycated hemoglobin levels ( 34059833 28898252) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549 28869591) Myocardial infarction ( 33532862) Prostate cancer ( 23023329) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) Takayasu arteritis ( 25604533) Tenofovir clearance in HIV infection ( 26148204)	Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		22 interacting genes: APP CREBBP DVL3 ELK1 EP300 FBXO7 GYS1 HDAC1 HDAC5 HGS HSF2BP KAT5 KLF6 MYO15B PAX9 PLK1 SETD7 SP1 TLE5 TP53 USP10 VHL	20 interacting genes: AR G3BP1 H2AC20 HDAC6 IKBKG KLF4 MAP1LC3B MSH2 NOTCH1 PRKAA2 RACK1 RAD51 SCNN1A SCNN1G SIRT6 SMAD4 SNX3 UBC WWTR1 YAP1
Entrez ID		9314	9100
HPRD ID		03769	07029
Ensembl ID		ENSG00000136826	ENSG00000103194
Uniprot IDs		O43474	A0A7G6J4N4 Q14694
PDB IDs
Enriched GO Terms of Interacting Partners?
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