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KLF4 and FBXO7
Number of citations of the paper that reports this interaction (PubMedID
27503909
)
14
Data Source:
BioGRID
(enzymatic study)
KLF4
FBXO7
Description
Kruppel like factor 4
F-box protein 7
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
SCF Ubiquitin Ligase Complex
Protein-containing Complex
Glial Cytoplasmic Inclusion
Classical Lewy Body
Lewy Neurite
Lewy Body Core
Lewy Body Corona
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Phosphatidylinositol 3-kinase Regulator Activity
Histone Deacetylase Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Protein Heterodimerization Activity
Ubiquitin Ligase-substrate Adaptor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Defense Response To Tumor Cell
Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Mesodermal Cell Fate Determination
Negative Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Muscle Hyperplasia
Negative Regulation Of Angiogenesis
Stem Cell Population Maintenance
Post-embryonic Camera-type Eye Development
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Interleukin-8 Production
Negative Regulation Of Heterotypic Cell-cell Adhesion
Post-embryonic Hemopoiesis
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Nitric Oxide Biosynthetic Process
Fat Cell Differentiation
Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hemoglobin Biosynthetic Process
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Axon Regeneration
Epidermis Morphogenesis
Negative Regulation Of Inflammatory Response
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of Telomerase Activity
Canonical Wnt Signaling Pathway
Negative Regulation Of Response To Cytokine Stimulus
Cellular Response To Hydrogen Peroxide
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Cellular Response To Cycloheximide
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Blastocyst Development
Cellular Response To Peptide
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Core Promoter Binding
Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Autophagy Of Mitochondrion
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Mitochondrion
Regulation Of Neuron Projection Development
Protein Ubiquitination
Regulation Of Protein Stability
Regulation Of Locomotion
Negative Regulation Of Lymphocyte Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Oxidative Stress-induced Neuron Death
Positive Regulation Of Autophagy Of Mitochondrion
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Transcriptional regulation of white adipocyte differentiation
Synthesis, secretion, and deacylation of Ghrelin
Transcriptional regulation of pluripotent stem cells
FOXO-mediated transcription of cell cycle genes
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Breast cancer (
21263130
)
Colorectal or endometrial cancer (
26621817
)
Coronary artery disease (
33020668
)
Cotinine glucuronidation (
25293881
)
Cutaneous malignant melanoma (
26237428
)
Glycated hemoglobin levels (
34059833
28898252
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Heel bone mineral density (
30598549
28869591
)
Myocardial infarction (
33532862
)
Prostate cancer (
23023329
)
Psoriasis (
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Takayasu arteritis (
25604533
)
Tenofovir clearance in HIV infection (
26148204
)
Blood protein levels (
29875488
)
Mean corpuscular hemoglobin (
29403010
32888494
27863252
)
Mean corpuscular volume (
29403010
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
27863252
)
Red blood cell traits (
23222517
)
Red cell distribution width (
32888494
27863252
)
Refractive error (
32231278
)
Interacting Genes
22 interacting genes:
APP
CREBBP
DVL3
ELK1
EP300
FBXO7
GYS1
HDAC1
HDAC5
HGS
HSF2BP
KAT5
KLF6
MYO15B
PAX9
PLK1
SETD7
SP1
TLE5
TP53
USP10
VHL
347 interacting genes:
AATF
ABCF3
ABL1
ACOT8
ACSL5
ACSM3
ACTC1
ACVR1
ACVR2B
AK8
AKAP14
AKIRIN2
AKT3
ALKBH3
AMOTL2
ANGPTL7
ANKRD36BP1
ANP32E
AP1B1
APEX1
APOBEC3C
APOBEC4
ASPH
ASPHD1
ATAT1
ATF5
ATP5F1C
BAG3
BCKDK
BIRC2
BLK
BUB1
BUB1B
C11orf16
C15orf48
C1orf105
C1orf115
C22orf31
C2orf88
CACYBP
CAMK1
CAPN5
CASQ2
CCBE1
CCDC186
CCDC60
CCDC88C
CCNE2
CDC34
CDK10
CDK14
CENPJ
CEP112
CFAP300
CHCHD2
CHCHD6
CHMP2B
CHMP3
CILK1
CIRBP
CKAP2
CLHC1
CLIP3
CMTR2
CNOT7
COLEC12
CPEB4
CRMA
CSNK1E
CXCL12
CXCL9
DDRGK1
DDX10
DHRS2
DHX40
DNAH14
DNAJA3
DNAJB12
DNAJC30
DPY19L2P1
DRAP1
ELF4
EP400P1
EPHA3
EPHB2
EPHB3
EPHB4
ERBB2
ERICH2
FGF10
FGF13
FGFR1
FGFR2
FMOD
FUT8
FYTTD1
GADD45GIP1
GAPDH
GBP2
GEMIN2
GGA2
GLCE
GLIPR2
GLRX2
GMCL2
GNLY
GORAB
GPAM
GPKOW
GRK6
GSK3B
H1-0
H2AZ2
H3-3B
HADH
HMG20A
HMG20B
HMGB2
HMGCS2
HNRNPK
HPF1
IDH2
IFT88
IGKV1-5
IL4
IL7
ILKAP
INKA2
INPP5K
INTS7
IPO9
IRF3
JADE2
KCNAB1
KCTD14
KHDRBS3
KIAA1586
KIF12
KIFC3
KIRREL3-AS3
KLF4
KMO
KPNA5
LETMD1
LGALS3BP
LIMK1
LIMK2
LINC01483
LMNA
LRRC20
LRRC8E
LRRFIP1
MAK
MAP2K6
MAPK10
MAPK9
MAPRE2
MARK2
MARK3
MBD5
MBNL1
MCM2
MCM5
MDK
MED22
MED27
MEF2D
MEST
MIS18BP1
MITF
MMP13
MMP8
MNDA
MOB3A
MOB3C
MPG
MPP3
MPZL1
MRM3
MRPL27
MRPS14
MTIF3
MTUS1
MYOG
NANS
NDE1
NFIA
NFIC
NFKB1
NKD2
NPHP1
NUDT16L1
NUMB
NVL
ODF2L
OLFML2A
OR14K1
ORC3
OSTF1
PABPC3
PACRG
PAFAH1B1
PAK6
PCBD2
PDCD7
PDE12
PDE4D
PDGFB
PGAP4
PHLDA1
PIEZO1
PIGY
PIM1
PIM2
PINK1
PLEKHA1
PNOC
PNRC2
POLDIP2
POLR2K
PPHLN1
PPP1CB
PPP1R17
PPP1R21
PRAME
PRICKLE2
PRKACB
PRKCA
PRKCB
PRKCG
PRKN
PRMT1
PRRC2B
PUF60
PUSL1
QKI
RBBP6
RBM23
RBM33
RCC1
REEP3
REEP4
RET
RGS1
RGS22
RNF121
RNF20
RORB
RPL14
RPL26
RPL36A
RPL37A
RPL3L
RPL6
RPS15A
RPS18
RPS19BP1
RPS2
RPS6KA3
RPS6KB1
RSL24D1
RWDD4
S100A13
S100A16
S100B
SAMHD1
SCARA5
SDCCAG8
SEC16B
SEC24C
SET
SFR1
SHANK3
SHMT1
SHMT2
SKP1
SLAIN1
SLC25A26
SLC35B3
SLC7A6OS
SMARCD1
SMOC2
SNAP25
SNRPA
SNX33
SPATA4
SPDYA
SPRY2
SRCIN1
SRPK3
SRSF10
SRSF7
SS18L2
STAT6
STYX
TAF9B
TARDBP
TBC1D3P2
TBPL1
TC2N
TCP10L3
TEAD4
TEC
TECR
TECRL
TENT5D
TEX29
TGIF2
THAP7
TLE3
TMED10
TMEM120A
TMEM237
TMOD2
TMPRSS5
TOMM20
TRAPPC12
TRIB3
TRIM44
TSBP1
TSLP
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2J2
UBE2M
UROD
USF1
USH1C
UXS1
VPS16
VRK3
WDR18
WDR24
XPO1
XRN1
YPEL5
ZBTB44
ZC2HC1C
ZFYVE21
ZKSCAN8
ZMYM5
ZNF462
ZNF574
ZNF684
ZNF688
Entrez ID
9314
25793
HPRD ID
03769
07292
Ensembl ID
ENSG00000136826
ENSG00000100225
Uniprot IDs
O43474
Q9Y3I1
PDB IDs
4L9C
4L9H
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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