S1PR2 and GNA13

Number of citations of the paper that reports this interaction (PubMedID 10488065)
92

Data Source:
HPRD (in vitro)

		S1PR2	GNA13
Description		sphingosine-1-phosphate receptor 2	G protein subunit alpha 13
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Integrin Binding Protein Binding Lipid Binding G Protein-coupled Peptide Receptor Activity Sphingosine-1-phosphate Receptor Activity	G Protein-coupled Receptor Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Sphingosine-1-phosphate Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Metabolic Process Actin Cytoskeleton Reorganization Filopodium Assembly Negative Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Activation Of Phospholipase D Activity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		G alpha (i) signalling events Lysosphingolipid and LPA receptors	NRAGE signals death through JNK G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)	Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)
Interacting Genes		4 interacting genes: GNA13 GNAI1 GNAQ KEAP1	31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR
Entrez ID		9294	10672
HPRD ID		05488	05100
Ensembl ID		ENSG00000267534	ENSG00000120063
Uniprot IDs		A0A024R7B2 O95136	A0A024R8M0 Q14344
PDB IDs		1ZTI
Enriched GO Terms of Interacting Partners?
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