GPR37L1 and CD46

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GPR37L1	CD46
Description		G protein-coupled receptor 37 like 1	CD46 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Receptor Complex Ciliary Membrane	Inner Acrosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Prosaposin Receptor Activity Peptide Binding	Virus Receptor Activity Protein Binding Signaling Receptor Activity Cadherin Binding
	Biological Process	Negative Regulation Of Systemic Arterial Blood Pressure Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Adaptive Immune Response T Cell Mediated Immunity Complement Activation, Classical Pathway Single Fertilization Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Interleukin-10 Production Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation, Classical Pathway Viral Entry Into Host Cell Positive Regulation Of Transforming Growth Factor Beta Production
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Regulation of Complement cascade
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Diverticular disease ( 30177863)	Age-related macular degeneration ( 23326517) Biomedical quantitative traits ( 19396169) Chronic central serous retinopathy ( 30073298) Drug experimentation measurement ( 30718321) Early age-related macular degeneration ( 32843070) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Heart rate ( 23583979) Immune response to measles vaccine (measles-specific neutralising antibody titre) ( 28289848) Keratoconus ( 33649486) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Refractive error ( 32231278) Resting heart rate ( 29769521 27798624) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27841878 30578418) White blood cell count ( 32888494)
Interacting Genes		52 interacting genes: ADGRB3 AQP1 AQP10 ARL13B CD46 CISD2 CLDN7 CLDND2 CLEC2A CREB3L1 CYB561A3 ELOVL4 ERG28 FAM209A FFAR2 FXYD3 FXYD6-FXYD2 GPR152 GPR42 GPX8 IGFBP5 INSIG2 JAGN1 LHFPL5 PDCD1LG2 PLN PRH1 RNF122 RPRM SCARB2 SCARF1 SEC22A SERP1 SLC30A8 STOM SYNPR THAP4 THSD7B TM4SF4 TMEM147 TMEM243 TMEM248 TMEM52B TMEM54 TMEM80 TMEM86A TMEM86B TMEM97 TNFRSF10C TSPAN12 UNC93B1 UPK1B	16 interacting genes: AGR3 ANKRD46 C3 DLG4 GPR37L1 ITGB1 LLGL1 MGAT5B MSN NEK2 POU4F2 PRKACA SRC TSPAN4 VTI1B YES1
Entrez ID		9283	4179
HPRD ID		13603	00406
Ensembl ID		ENSG00000170075	ENSG00000117335
Uniprot IDs		O60883	P15529
PDB IDs			1CKL 1HR4 2O39 3INB 3L89 3O8E 5FO8
Enriched GO Terms of Interacting Partners?
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