EXO1 and YWHAB

Number of citations of the paper that reports this interaction (PubMedID 24255178)
195

Data Source:
BioGRID (two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology)

		EXO1	YWHAB
Description		exonuclease 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Body	Nucleus Cytoplasm Vacuolar Membrane Cytosol Focal Adhesion Membrane Transcription Repressor Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity 5'-3' Exodeoxyribonuclease Activity Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity	Protein Kinase Inhibitor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Deacetylase Binding Protein-containing Complex Binding Cadherin Binding Phosphoserine Residue Binding Phosphoprotein Binding
	Biological Process	Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Repair Mismatch Repair DNA Recombination Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle RNA Phosphodiester Bond Hydrolysis, Endonucleolytic T-circle Formation	Protein Targeting Signal Transduction Cellular Protein Localization Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Cytoplasmic Sequestering Of Protein
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane MTOR signalling mTORC1-mediated signalling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signaling by Hippo Rap1 signalling Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA RHO GTPases activate PKNs TP53 Regulates Metabolic Genes RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs			Copper Phenethyl Isothiocyanate
Diseases
GWAS		Basal cell carcinoma ( 31174203) Breast cancer ( 25751625 29059683) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Mean platelet volume ( 32888494)
Interacting Genes		21 interacting genes: ATM BLM DCAF1 H4C1 KPNA4 KPNB1 MLH1 MLH3 MSH2 MSH3 PCNA PMS2 SENP6 SFN UBE2I YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	143 interacting genes: ABL1 ADAM22 AFDN AKAP13 ALS2 APP ATP5F1A BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DCAF7 DHX15 DYRK1A EDC3 EGFR EPB41 EPB41L1 EPB41L3 ERRFI1 EXO1 FER FRMD6 GAPVD1 GEM H3C1 HDAC5 HES1 HSP90AB1 HSPA1A HSPA1B HSPA5 HSPB1 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLXIP MPRIP MST1R MTNR1A MTNR1B OSBPL3 PARD3 PARD6B PDCL2 PDE3B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1
Entrez ID		9156	7529
HPRD ID		06932	03184
Ensembl ID		ENSG00000174371	ENSG00000166913
Uniprot IDs		A8K5H6 Q9UQ84	P31946 V9HWD6
PDB IDs		3QE9 3QEA 3QEB 5UZV 5V04 5V05 5V06 5V07 5V08 5V09 5V0A 5V0B 5V0C 5V0D 5V0E	2BQ0 2C23 4DNK 5N10 6A5Q 6BYK 6GN0 6GN8 6GNJ 6GNK 6GNN 6HEP
Enriched GO Terms of Interacting Partners?
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