EXO1 and MSH3

Number of citations of the paper that reports this interaction (PubMedID 11427529)
55

Data Source:
HPRD (in vitro, in vivo)

		EXO1	MSH3
Description		exonuclease 1	mutS homolog 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Body	Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSbeta Complex
	Molecular Function	DNA Binding Chromatin Binding RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity 5'-3' Exodeoxyribonuclease Activity Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity	Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Enzyme Binding Mismatched DNA Binding DNA Insertion Or Deletion Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity
	Biological Process	Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Repair Mismatch Repair DNA Recombination Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle RNA Phosphodiester Bond Hydrolysis, Endonucleolytic T-circle Formation	DNA Repair Mismatch Repair Mitotic Recombination Reciprocal Meiotic Recombination Somatic Recombination Of Immunoglobulin Gene Segments Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2
Drugs
Diseases
GWAS		Basal cell carcinoma ( 31174203) Breast cancer ( 25751625 29059683) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Huntington's disease progression ( 28642124) Idiopathic downbeat nystagmus ( 32157568) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		21 interacting genes: ATM BLM DCAF1 H4C1 KPNA4 KPNB1 MLH1 MLH3 MSH2 MSH3 PCNA PMS2 SENP6 SFN UBE2I YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	14 interacting genes: BARD1 BRCA1 EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 RPA4 SUMO2 TSC22D2 XPA
Entrez ID		9156	4437
HPRD ID		06932	02931
Ensembl ID		ENSG00000174371	ENSG00000113318
Uniprot IDs		A8K5H6 Q9UQ84	P20585
PDB IDs		3QE9 3QEA 3QEB 5UZV 5V04 5V05 5V06 5V07 5V08 5V09 5V0A 5V0B 5V0C 5V0D 5V0E	3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?
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