CBFA2T2 and RUNX1

Number of citations of the paper that reports this interaction (PubMedID 10675041)
6

Data Source:
HPRD (in vitro)

		CBFA2T2	RUNX1
Description		CBFA2/RUNX1 partner transcriptional co-repressor 2	RUNX family transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Core-binding Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Corepressor Activity Protein Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription, DNA-templated Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Intestinal Epithelial Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Ossification Chondrocyte Differentiation Myeloid Leukocyte Differentiation Regulation Of Transcription By RNA Polymerase II Regulation Of Plasminogen Activation Hemopoiesis Neuron Differentiation Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Tissue Regeneration Hematopoietic Stem Cell Proliferation Positive Regulation Of Extracellular Matrix Organization Regulation Of Connective Tissue Replacement
Pathways			Pre-NOTCH Transcription and Translation Organic cation transport RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling RUNX2 regulates genes involved in differentiation of myeloid cells RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Triglyceride levels ( 32203549)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 31036433 30929738) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Brain-derived neurotrophic factor levels ( 33345186) Breast cancer ( 31757997) Celiac disease and Rheumatoid arthritis ( 26546613) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Femoral neck length ( 30888730) Gut microbiota alpha diversity (Chao1 index) ( 33208821) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip index ( 34021172) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391) Immune response to smallpox vaccine (IL-6) ( 22542470) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Male-pattern baldness ( 29146897 27182965 28196072) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of granulocytes ( 27863252) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Preeclampsia ( 23551011) Psoriasis ( 25903422) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Stroke ( 32693751) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		34 interacting genes: APP ATN1 ATXN1L BAG4 CBFA2T3 CBFB CEP83 FBXL19 GTF2E1 ID3 KIFC3 KRTAP13-2 LBP MAGEA6 MDFI NCOR1 NCOR2 NEUROG1 NOTCH3 NTAQ1 PDP1 PHAF1 PRDM14 PRDM6 RERE RUNX1 SIKE1 SIN3A SORBS3 TAL2 TCF4 TCP1 ZC2HC1A ZNF652	76 interacting genes: AR BAG3 BAG4 CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CCNK CDK1 CDK6 CEBPA CEBPB COL6A1 COL6A2 COPRS CRYAA CSTB DNMT1 DTX2 DZIP3 ELF1 ELF2 ELF4 EP300 FAM222B FBXO17 FOS FOXP3 GCC1 GSK3A HGS HIPK1 HIPK2 IKZF1 IKZF3 JUN KAT6A KAT6B MAPK1 MYOD1 NCOR1 NCOR2 NEDD4 NFKBID OLIG3 PAX5 PHTF1 PRMT1 PTPN12 PTTG1IP RBM14 RNF38 RNF44 SNRPC SPEN SPI1 SUV39H1 TAFAZZIN TEAD2 TEAD4 TEKT5 TLE1 TLE2 TLE5 TNR TRIM5 UBE2L6 UHRF2 UXT VDR VPS37C WWP1 WWTR1 YAP1
Entrez ID		9139	861
HPRD ID		04721	01043
Ensembl ID		ENSG00000078699	ENSG00000159216
Uniprot IDs		O43439	Q01196
PDB IDs			1CMO 1CO1 1E50 1H9D 1LJM
Enriched GO Terms of Interacting Partners?
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