LATS1 and TAFAZZIN

Number of citations of the paper that reports this interaction (PubMedID 24107629)
33

Data Source:
BioGRID (unspecified method)

		LATS1	TAFAZZIN
Description		large tumor suppressor kinase 1	tafazzin, phospholipid-lysophospholipid transacylase
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Microtubule Organizing Center Cytosol Midbody	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Estrogen Receptor Binding Protein Serine Kinase Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity O-acyltransferase Activity 1-acylglycerophosphocholine O-acyltransferase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-serine Phosphorylation Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cytoplasmic Sequestering Of Protein Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process	Mitophagy Heart Morphogenesis Muscle Contraction Mitochondrion Organization Inner Mitochondrial Membrane Organization Heart Development Skeletal Muscle Tissue Development Hemopoiesis Cardiolipin Metabolic Process Cardiolipin Biosynthetic Process Mitochondrial Respiratory Chain Complex I Assembly Cardiolipin Acyl-chain Remodeling Cristae Formation Mitochondrial ATP Synthesis Coupled Electron Transport Spermatocyte Division Cardiac Muscle Tissue Development Cardiac Muscle Contraction Positive Regulation Of Cardiolipin Metabolic Process Positive Regulation Of ATP Biosynthetic Process
Pathways		Signaling by Hippo	Mitochondrial protein import Mitochondrial protein import Acyl chain remodeling of CL
Drugs		Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)
Interacting Genes		46 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LRRK2 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK3 STK4 SYNE1 TAFAZZIN TFIP11 TRAF1 UBE2I WWOX WWP1 WWTR1 ZYX	16 interacting genes: BTRC CCDC88C CHGB CSNK1E GSK3B LATS1 LATS2 OPN1LW RPL10 RUNX1 SLC6A8 SLC9A3R2 SSR4 TRAK2 VBP1 YWHAE
Entrez ID		9113	6901
HPRD ID		09147	02316
Ensembl ID		ENSG00000131023	ENSG00000102125
Uniprot IDs		O95835	A0A0S2Z4E6 A0A0S2Z4F4 A0A0S2Z4K0 A0A0S2Z4K9 A0A494C0C5 A0A499FJ53 A6XNE1 Q16635
PDB IDs		4ZRK 5B5W 5BRK
Enriched GO Terms of Interacting Partners?
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