LATS1 and STK3

Number of citations of the paper that reports this interaction (PubMedID 15688006)
241

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study)

		LATS1	STK3
Description		large tumor suppressor kinase 1	serine/threonine kinase 3
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Microtubule Organizing Center Cytosol Midbody	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Estrogen Receptor Binding Protein Serine Kinase Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-serine Phosphorylation Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cytoplasmic Sequestering Of Protein Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Protein Tetramerization Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Signaling by Hippo	Signaling by Hippo
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		46 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LRRK2 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK3 STK4 SYNE1 TAFAZZIN TFIP11 TRAF1 UBE2I WWOX WWP1 WWTR1 ZYX	42 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB1B MOB3B MOB4 MPP1 OGT ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		9113	6788
HPRD ID		09147	05433
Ensembl ID		ENSG00000131023	ENSG00000104375
Uniprot IDs		O95835	A0A087WZ06 A0A384MR07 Q13188
PDB IDs		4ZRK 5B5W 5BRK	3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2
Enriched GO Terms of Interacting Partners?
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