PYGO2 and SUPT3H

Number of citations of the paper that reports this interaction (PubMedID 20937768)
28

Data Source:
BioGRID (pull down)

		PYGO2	SUPT3H
Description		pygopus family PHD finger 2	SPT3 homolog, SAGA and STAGA complex component
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Beta-catenin-TCF Complex	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFTC Complex
	Molecular Function	Chromatin Binding Protein Binding Histone Acetyltransferase Regulator Activity Histone Binding Metal Ion Binding	Transcription Coactivator Activity Protein Heterodimerization Activity
	Biological Process	Kidney Development Lens Development In Camera-type Eye Spermatid Nucleus Differentiation Brain Development Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Chromatin Binding Developmental Growth Regulation Of Histone H3-K4 Methylation Roof Of Mouth Development Canonical Wnt Signaling Pathway	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Histone Deubiquitination Histone H3 Acetylation Positive Regulation Of Transcription, DNA-templated
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex	HATs acetylate histones
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)	ADAMTS13 activity ( 25934476) Attention deficit hyperactivity disorder ( 18839057) Chin dimples ( 27182965) Estimated glomerular filtration rate ( 31152163) facial morphology traits (multivariate analysis) ( 27193062) Glaucoma ( 31959993) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 25429064 19893584 23563607 31562340 18391951) Hip circumference adjusted for BMI ( 34021172) Hip minimal joint space width ( 27701424) Intraocular pressure ( 31959993 30054594) Large artery stroke ( 24262325) Lumbar spine bone mineral density ( 22504420) Lymphocyte counts ( 32888494) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Nose morphology ( 29921221) Nose size ( 27182965) Obesity-related traits ( 23251661) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Osteoarthritis ( 22763110) Osteoarthritis of the hand ( 28855172) Osteoarthritis of the hip or knee ( 30664745) Post bronchodilator FEV1/FVC ratio ( 26634245) Serum alkaline phosphatase levels ( 33547301) Stroke (ischemic) ( 22941190) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: AKT1 BCL9 DCAF1 KAT2A NF2 SUPT3H TRRAP	5 interacting genes: DDB1 H3-4 MYC PYGO2 TCF3
Entrez ID		90780	8464
HPRD ID		06065	04254
Ensembl ID		ENSG00000163348	ENSG00000196284
Uniprot IDs		Q5T170 Q9BRQ0	A0A024RD67 B4E1H0 O75486
PDB IDs		2XB1 4UP0 4UP5
Enriched GO Terms of Interacting Partners?
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