SEC11C and STX12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SEC11C	STX12
Description		SEC11 homolog C, signal peptidase complex subunit	syntaxin 12
Image		No pdb structure
GO Annotations	Cellular Component	Signal Peptidase Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Golgi Membrane Phagophore Assembly Site Nucleoplasm Golgi Apparatus Synaptic Vesicle Endomembrane System Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane SNARE Complex Early Endosome Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Phagocytic Vesicle Recycling Endosome Membrane Postsynaptic Recycling Endosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Signal Peptide Processing	Autophagosome Assembly Intracellular Protein Transport Vesicle Fusion Cholesterol Efflux Vesicle Docking Protein Stabilization
Pathways		SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		23 interacting genes: BTN2A2 C2 CADM3 GLP1R HMOX1 MFF PLPP6 PRSS23 RTP2 SCD SELENOM SERP1 STX12 TMEM128 TMEM243 TMEM254 TMEM42 TREX1 TSNARE1 UBE2J1 VAMP1 VAMP4 VAPA	43 interacting genes: AQP6 AQP8 BCL2L13 BLOC1S6 CD79A CISD2 DNAJC5 DTX2 EBP EEA1 EPB42 ERGIC3 FCER1G GORAB HOMER1 KASH5 LEPROTL1 LMNA MFSD6 MMGT1 NAPA NEMP1 NSG1 PDZK1IP1 PLPPR2 RIC3 SEC11C SLC10A6 SLC66A2 SNAP23 SNAP25 SNAP29 STX1A STX2 STX4 STXBP5L TIMMDC1 TLCD4 TMEM14B TMEM167B TMEM31 TMEM86B TMX2
Entrez ID		90701	23673
HPRD ID		15310	06059
Ensembl ID		ENSG00000166562	ENSG00000117758
Uniprot IDs		K7EJQ7 Q9BY50	Q86Y82
PDB IDs			2DNX
Enriched GO Terms of Interacting Partners?
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