SQSTM1 and GRIA1

Number of citations of the paper that reports this interaction (PubMedID 19004011)
19

Data Source:
HPRD (in vivo, in vitro)

		SQSTM1	GRIA1
Description		sequestosome 1	glutamate ionotropic receptor AMPA type subunit 1
Image
GO Annotations	Cellular Component	Phagophore Assembly Site P-body Nucleoplasm Cytoplasm Mitochondrion Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Intracellular Membrane-bounded Organelle Amphisome Autolysosome Extracellular Exosome Sperm Midpiece Lewy Body	Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Postsynaptic Density Dendrite Endocytic Vesicle Membrane Synaptic Vesicle Membrane Early Endosome Membrane AMPA Glutamate Receptor Complex Dendritic Spine Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Neuronal Cell Body Dendritic Spine Axonal Spine Neuron Spine Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Synaptic Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane Perisynaptic Space
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Amyloid-beta Binding AMPA Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Positive Regulation Of Protein Phosphorylation Immune System Process Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Apoptotic Process Endosome Organization Protein Localization Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Negative Regulation Of Protein Ubiquitination Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Selective Autophagy Response To Mitochondrial Depolarisation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm	Signal Transduction Chemical Synaptic Transmission Long-term Memory Receptor Internalization Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Depression Cellular Response To Ammonium Ion Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Pathways		NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Interleukin-1 signaling Pexophagy Signaling by ALK fusions and activated point mutants	COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules Long-term potentiation
Drugs			Glutamic acid Butabarbital Lamotrigine Isoflurane Ethanol Methoxyflurane Desflurane Sevoflurane Talampanel CX-717 CX516 Perampanel Tianeptine Fluciclovine (18F)
Diseases
GWAS		Alzheimer's disease (late onset) ( 24162737) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Adult body size ( 32376654) Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Interleukin-6 levels ( 22205395) Middle childhood and early adolescence aggressive behavior ( 26087016) Morning person ( 30696823) Obesity-related traits ( 23251661) Post bronchodilator FEV1 in COPD ( 26634245) Schizophrenia ( 28991256 25056061 30285260 23974872) Sleep (1/3-day periodicity) ( 33075057) Sudden cardiac arrest ( 21658281) Survival in microsatellite instability low/stable colorectal cancer ( 25866641)
Interacting Genes		108 interacting genes: ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CALR CAMK2A CCNB1 CDC37 CDC6 CDK1 CRBN CRYAB CSNK1A1 CSNK2A1 DAXX DAZAP2 DNAI1 DNAI2 DNAJC10 EEF1D FKBP4 GABARAP GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPA5 HSPB1 IKBKB IRAK1 KAT5 KCNAB2 KEAP1 LCK LINC01554 LRRK2 MALT1 MAP1LC3B MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MTDH NBR1 NCOR1 NEDD4 NR2F2 NSD3 NTRK1 NTRK2 NTRK3 OGT PADI1 PAWR PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RPL37 SKP2 SLIT3 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TBK1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIB3 TRIM21 TRIM55 TRIM63 TTN UBA52 UBB UBE2D2 UBE2D3 ULK2 USP8 VANGL2 WDR81 XIAP YWHAZ	27 interacting genes: CACNG2 CAMK2A CAMK2G CANX CASP8 CXCR2 DLG1 EPB41L1 EPB41L2 FLT4 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 NEDD4L PICK1 PRKACA PRKCA RPS6KB1 SDCBP SQSTM1 TANC1 TRPC1 USP46
Entrez ID		8878	2890
HPRD ID		03319	00695
Ensembl ID		ENSG00000161011	ENSG00000155511
Uniprot IDs		Q13501	P42261 Q59GL5
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6JM4 6KHZ 6MJ7 6TGY 6TH3	6X5Q
Enriched GO Terms of Interacting Partners?
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