SQSTM1 and TOE1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		SQSTM1	TOE1
Description		sequestosome 1	target of EGR1, exonuclease
Image
GO Annotations	Cellular Component	Phagophore Assembly Site P-body Nucleoplasm Cytoplasm Mitochondrion Late Endosome Autophagosome Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Sarcomere Intracellular Membrane-bounded Organelle Amphisome Autolysosome Extracellular Exosome Sperm Midpiece Lewy Body	Nucleoplasm Nucleolus Cytoplasm Cajal Body Nuclear Body Nuclear Speck
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding SH2 Domain Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	3'-5'-exoribonuclease Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding SnRNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Autophagy Of Mitochondrion Mitophagy Positive Regulation Of Protein Phosphorylation Immune System Process Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Apoptotic Process Endosome Organization Protein Localization Regulation Of Mitochondrion Organization Endosomal Transport Macroautophagy Cell Differentiation Negative Regulation Of Protein Ubiquitination Intracellular Signal Transduction Aggrephagy Positive Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ras Protein Signal Transduction Regulation Of Protein Complex Stability Selective Autophagy Response To Mitochondrial Depolarisation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Perinuclear Region Of Cytoplasm	SnRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Interleukin-1 signaling Pexophagy Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 24162737) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		108 interacting genes: ATXN3 BCL2 BMPR1B BPTF BRCA1 CALCR CALM1 CALR CAMK2A CCNB1 CDC37 CDC6 CDK1 CRBN CRYAB CSNK1A1 CSNK2A1 DAXX DAZAP2 DNAI1 DNAI2 DNAJC10 EEF1D FKBP4 GABARAP GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 HSPA5 HSPB1 IKBKB IRAK1 KAT5 KCNAB2 KEAP1 LCK LINC01554 LRRK2 MALT1 MAP1LC3B MAP2K5 MAPK13 MAPK14 MAPT MBP MEIS2 MLH1 MTDH NBR1 NCOR1 NEDD4 NR2F2 NSD3 NTRK1 NTRK2 NTRK3 OGT PADI1 PAWR PIK3CA PIK3R1 PPHLN1 PRKCD PRKCI PRKCZ RAD23A RAD54L2 RELN RIPK1 RNF166 RNF168 RPL37 SKP2 SLIT3 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TBK1 TGFBR1 TKT TOE1 TP53INP1 TRAF6 TRIB3 TRIM21 TRIM55 TRIM63 TTN UBA52 UBB UBE2D2 UBE2D3 ULK2 USP8 VANGL2 WDR81 XIAP YWHAZ	26 interacting genes: ABCF3 AGGF1 AP2A1 APLP1 CA12 HNRNPF IK IL7R LSM4 OGT PPP1CA PRCC RAB40C RBM39 RBM8A RPS3A SF3B2 SF3B3 SH3GL3 SQSTM1 SRSF6 SUMO1 U2AF1 UNC13B WDR77 WDR83
Entrez ID		8878	114034
HPRD ID		03319	18212
Ensembl ID		ENSG00000161011	ENSG00000132773
Uniprot IDs		Q13501	Q96GM8
PDB IDs		1Q02 2JY7 2JY8 2K0B 2KNV 4MJS 4UF8 4UF9 5YP7 5YP8 5YPA 5YPB 5YPC 5YPE 5YPF 5YPG 5YPH 6JM4 6KHZ 6MJ7 6TGY 6TH3	2FC6
Enriched GO Terms of Interacting Partners?
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