SYNJ1 and SH3BP1

Number of citations of the paper that reports this interaction (PubMedID 10764144)
9

Data Source:
HPRD (two hybrid, in vivo)

		SYNJ1	SH3BP1
Description		synaptojanin 1	SH3 domain binding protein 1
Image
GO Annotations	Cellular Component	Cytosol Microtubule Vesicle Membrane Membrane Coat Clathrin Coat Of Coated Pit Terminal Bouton Perinuclear Region Of Cytoplasm Synaptic Membrane Parallel Fiber To Purkinje Cell Synapse Presynapse	Phagocytic Cup Intracellular Anatomical Structure Nucleus Cytosol Adherens Junction Bicellular Tight Junction Lamellipodium Cell Leading Edge
	Molecular Function	RNA Binding Phosphatidylinositol-3-phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein C-terminus Binding SH3 Domain Binding Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Protein-containing Complex Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity EH Domain Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding Semaphorin Receptor Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Neurotransmitter Transport Brain Development Learning Positive Regulation Of Gliogenesis Synaptic Vesicle Priming Synaptic Vesicle Uncoating Response To Retinoic Acid Response To Cytokine Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Membrane Organization Positive Regulation Of Endosome Organization	Phagocytosis, Engulfment Actin Filament Organization Cell Migration Regulation Of Actin Filament Depolymerization Regulation Of Actin Cytoskeleton Organization Cell Junction Assembly Regulation Of Rac Protein Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Clathrin-mediated endocytosis	RAC1 GTPase cycle
Drugs
Diseases
GWAS		Platelet reactivity in response to clopidogrel treatment ( 32472697)
Interacting Genes		25 interacting genes: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 GRB2 ITSN1 LRRK2 PACSIN1 PACSIN2 PACSIN3 PPP3CA SH3BP1 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SORBS2 VPS26C	16 interacting genes: ABI2 ABI3 ABL1 CCDC146 CRK FGA HCK NGLY1 POT1 RAC1 RHOA SRC SUN2 SYNJ1 TERF1 TRIP10
Entrez ID		8867	23616
HPRD ID		09182	10227
Ensembl ID		ENSG00000159082	ENSG00000100092
Uniprot IDs		A0A0D9SGJ6 B9EGN3 C9JFZ1 J3KQV8 O43426 Q05CZ1	A0A2X0SFX7 Q9Y3L3
PDB IDs		1W80 2DNR 2VJ0 7A0V	4J9D 4J9F
Enriched GO Terms of Interacting Partners?
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