TNFRSF10A and RASSF1

Number of citations of the paper that reports this interaction (PubMedID 15949439)
67

Data Source:
HPRD (in vivo)

		TNFRSF10A	RASSF1
Description		TNF receptor superfamily member 10a	Ras association domain family member 1
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GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Membrane Raft	Spindle Pole Nucleus Cytoplasm Microtubule Organizing Center Microtubule Microtubule Cytoskeleton
	Molecular Function	Protease Binding Death Receptor Activity Protein Binding Transcription Factor Binding Signaling Receptor Activity Identical Protein Binding TRAIL Binding	Protein Binding Zinc Ion Binding
	Biological Process	Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway	Cell Cycle Signal Transduction Ras Protein Signal Transduction Regulation Of Cell Cycle Regulation Of Microtubule Cytoskeleton Organization
Pathways		Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 21909106 23455636) Attention deficit hyperactivity disorder ( 20732625) Central serous retinopathy ( 31872073) Early age-related macular degeneration ( 32843070)	Basophil percentage of white cells ( 32888494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 28991256 30285260) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		15 interacting genes: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD	73 interacting genes: AKT1 ARAF ATM ATP2B4 ATR ATRX AURKA AURKB BANF1 BRAF C7orf25 C8orf33 CCND2 CCNE1 CDC20 CDK4 CDK6 CDKN2A CDKN2B CLNK CNKSR1 DAXX DDB1 E4F1 EPHA2 ERBB2 EXOSC8 FGFR4 FZR1 GLIS2 GRM1 HRAS IGFBP5 KAT2A KCNE3 KDELR2 KDM1A LARS2 LATS2 MAP1B MAP1S MAP2K3 MAP2K6 MAPK8 MDM2 MET MOAP1 MST1 MYC NF2 NUDT10 PFDN5 PRKDC RAF1 RASSF5 RELA RHOA RHOU SMARCA4 STK11 STK4 SUV39H1 SUV39H2 TEAD2 TERT TMEM115 TMEM158 TNFRSF10A TNFRSF1A TSC1 TUBB TUBG1 XPA
Entrez ID		8797	11186
HPRD ID		04679	05470
Ensembl ID		ENSG00000104689	ENSG00000068028
Uniprot IDs		O00220	Q9NS23
PDB IDs		5CIR	2KZU
Enriched GO Terms of Interacting Partners?
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