CASK and NRXN2

Number of citations of the paper that reports this interaction (PubMedID 8786425)
163

Data Source:
HPRD (two hybrid, in vitro)

		CASK	NRXN2
Description		calcium/calmodulin dependent serine protein kinase	neurexin 2
Image
GO Annotations	Cellular Component	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Basolateral Plasma Membrane Nuclear Matrix Vesicle Presynaptic Membrane Ciliary Membrane Schaffer Collateral - CA1 Synapse	Plasma Membrane Integral Component Of Membrane Protein-containing Complex Presynapse
	Molecular Function	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Neurexin Family Protein Binding Protein Serine Kinase Activity	Transmembrane Signaling Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Transcription By RNA Polymerase II GMP Metabolic Process GDP Metabolic Process Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Synaptic Vesicle Exocytosis	Neuron Cell-cell Adhesion Signal Transduction Chemical Synaptic Transmission Neurotransmitter Secretion Synapse Assembly Adult Behavior Social Behavior Vocal Learning Vocalization Behavior Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering
Pathways		Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins
Drugs		Formic acid Fostamatinib
Diseases
GWAS			Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 29273807) Gout ( 33832965) Lymphocyte counts ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Serum uric acid levels ( 30993211 29403010) Urate levels ( 21768215 23263486) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 29558500)
Interacting Genes		87 interacting genes: AKAP9 APBA1 ATP2B4 BNIP3L C20orf85 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DDX54 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBIN F11R FCHSD2 FMR1 GCNT3 GLS2 GRIK2 GRIN2A GTSE1 HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 KIF2A KLC4 LIN7A LIN7B MAPRE1 MAPRE2 MARK2 MARS1 MED1 MLLT6 MLX NDEL1 NPHS1 NRXN1 NRXN2 NRXN3 NTN4 P2RX7 PARD3B PARD6G PCBP2 PCM1 PKP2 PLK2 PPP4R3A PRC1 PRKCI PRKD2 PRKN PRPF3 PTGS2 RAB3A RBBP6 RBM10 RBM14 RBM5 RPA2 RPH3A SDC1 SDC2 SDC3 SDC4 SF3B2 SH2D4A SLAIN2 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WHRN WNT7B YWHAE	9 interacting genes: AFDN CASK DDX24 MACF1 MAPK6 NLGN1 NLGN2 NLGN3 PATJ
Entrez ID		8573	9379
HPRD ID		02164	11859
Ensembl ID		ENSG00000147044	ENSG00000110076
Uniprot IDs		A0A2R8Y6F8 A0A2R8YE77 A0A7I2RJN6 O14936	G5E9G7 P58401 Q9P2S2
PDB IDs		1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC 6KMH	4NXR
Enriched GO Terms of Interacting Partners?
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