NRXN2 and NLGN2

Number of citations of the paper that reports this interaction (PubMedID 8576240)
165

Data Source:
BioGRID (pull down)

		NRXN2	NLGN2
Description		neurexin 2	neuroligin 2
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Protein-containing Complex Presynapse	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Inhibitory Synapse Spanning Component Of Membrane Glycinergic Synapse Dopaminergic Synapse Symmetric, GABA-ergic, Inhibitory Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Channel Regulator Activity Metal Ion Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding	Signaling Receptor Activity Neurexin Family Protein Binding Identical Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Neuron Cell-cell Adhesion Signal Transduction Chemical Synaptic Transmission Neurotransmitter Secretion Synapse Assembly Adult Behavior Social Behavior Vocal Learning Vocalization Behavior Postsynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Sensory Perception Of Pain Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Protein Localization To Synapse Locomotory Exploration Behavior Cell-cell Junction Maintenance Synaptic Vesicle Endocytosis Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Terminal Button Organization Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gephyrin Clustering Involved In Postsynaptic Density Assembly Postsynaptic Density Protein 95 Clustering Positive Regulation Of Inhibitory Postsynaptic Potential Cell-cell Adhesion Presynapse Assembly Positive Regulation Of Protein Localization To Synapse Inhibitory Synapse Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering
Pathways		Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins Neurexins and neuroligins	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 29273807) Gout ( 33832965) Lymphocyte counts ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Serum uric acid levels ( 30993211 29403010) Urate levels ( 21768215 23263486) Urate levels in lean individuals ( 25811787) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 29558500)	Refractive error ( 32231278) Uterine fibroids ( 30194396) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: AFDN CASK DDX24 MACF1 MAPK6 NLGN1 NLGN2 NLGN3 PATJ	9 interacting genes: DLG2 DLG3 DLG4 DNAH9 MDGA1 NRXN1 NRXN2 NRXN3 PATJ
Entrez ID		9379	57555
HPRD ID		11859	07348
Ensembl ID		ENSG00000110076	ENSG00000169992
Uniprot IDs		G5E9G7 P58401 Q9P2S2	Q8NFZ4
PDB IDs		4NXR	5XEQ
Enriched GO Terms of Interacting Partners?
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