PPFIA2 and SMARCA2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		PPFIA2	SMARCA2
Description		PTPRF interacting protein alpha 2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cell Surface Axon Dendritic Spine Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex
	Molecular Function	Protein Binding Structural Constituent Of Presynapse	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity Histone Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Cell-matrix Adhesion Synapse Organization Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Presynapse Organization Dense Core Granule Cytoskeletal Transport Regulation Of Synaptic Vesicle Exocytosis	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatid Development Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases
GWAS		Age-related cataracts (age at onset) ( 25352737) Alcohol dependence ( 26365420) Delirium ( 29631748) Lean body mass ( 28552196) Post bronchodilator FEV1 ( 26634245) Resting heart rate ( 27798624) Schizophrenia ( 22885689)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma (childhood onset) ( 27611488) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Brain morphology (MOSTest) ( 32665545) Lead levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Neuritic plaque ( 31497858) Nose size ( 27182965) Parkinson's disease ( 26227905) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 26969751) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955)
Interacting Genes		16 interacting genes: CAST CDC5L ERC2 GIT1 IPO13 ITSN1 MTDH PPFIA1 PPFIA3 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRS SMARCA2 TSC1	54 interacting genes: ACTL6A ACTL6B ACTN2 ANO10 APC2 AR ARID1B BEND7 BRCA1 CCDC136 CEBPA CEP72 CNTROB CXXC1 DAB2IP DNM2 ESR1 GAPDH GCC1 GFAP H3C1 HSPB1 ITPRID2 KHDRBS1 LAMC1 MDM2 MDM4 MECP2 MPRIP MYB MYC MYO5B NECAB2 NR0B2 NR3C1 NR4A2 NUP62 PHB PICK1 PITX1 PPFIA2 PPP1R12C PRMT5 PRPF6 RAP1A SDCBP SIN3B SMARCC2 SPAG5 SS18 SUPT4H1 TACC2 TNFAIP1 ZNF821
Entrez ID		8499	6595
HPRD ID		04392	02483
Ensembl ID		ENSG00000139220	ENSG00000080503
Uniprot IDs		B7Z7Y5 G3V200 H0YHK3 O75334 Q4LE62	B1ALF6 B4DNT1 B4DSC8 F6T8Q0 F6VDE0 P51531 Q56A76 Q8N9Q1
PDB IDs		3TAC 3TAD 6IUH	2DAT 4QY4 5DKC 5DKH 6EG2 6EG3 6HAX 6HAY 6HAZ
Enriched GO Terms of Interacting Partners?
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