CUL4B and PWP1

Number of citations of the paper that reports this interaction (PubMedID 31973889)
8

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CUL4B	PWP1
Description		cullin 4B	PWP1 homolog, endonuclein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Chromosome Nucleolus Golgi Apparatus
	Molecular Function	Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding	H4K20me3 Modified Histone Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Proteasomal Protein Catabolic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Projection Development Histone H2A Monoubiquitination Ribosome Biogenesis UV-damage Excision Repair	Transcription, DNA-templated RRNA Processing Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Histone H4-K20 Trimethylation Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Stem Cell Differentiation
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases
GWAS			Acne (severe) ( 24927181)
Interacting Genes		55 interacting genes: AHR AMBRA1 APP AR BRWD1 BRWD3 CAND1 COMMD1 COP1 COPS2 COPS5 CRBN CUL4A DCAF10 DCAF11 DCAF12 DCAF15 DCAF16 DCAF17 DCAF4 DCAF5 DCAF6 DCUN1D1 DCUN1D4 DDA1 DDB1 DDB2 DET1 DNMT3B DTL ERCC8 ESR1 GLMN HUWE1 KPNA2 KPNA4 KPNB1 NEDD8 PHIP PLS3 PRDX3 PTEN PWP1 RBX1 RNF7 SALL2 SIN3A SRC ST7 TBL3 TRPC4AP UBC UBE2D3 WDTC1 ZMAT4	9 interacting genes: APP CKAP4 CUL4B DAPK1 DCAF1 HOXA3 NFYA OGT SMURF1
Entrez ID		8450	11137
HPRD ID		02251	11464
Ensembl ID		ENSG00000158290	ENSG00000136045
Uniprot IDs		K4DI93 Q13620	A0A024RBH5 B4DJV5 Q13610
PDB IDs		2DO7 4A0C 4A0L 4A64
Enriched GO Terms of Interacting Partners?
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