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MCRIP2 and PIK3CD
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
888
Data Source:
HPRD
(two hybrid)
MCRIP2
PIK3CD
Description
MAPK regulated corepressor interacting protein 2
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytoplasmic Stress Granule
Cytoplasm
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Membrane
Molecular Function
Protein Binding
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Phosphatidylinositol 3-kinase Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Phosphatidylinositol Kinase Activity
Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
Biological Process
Natural Killer Cell Differentiation
Positive Regulation Of Cytokine Production
Positive Regulation Of Endothelial Cell Proliferation
Adaptive Immune Response
Mast Cell Chemotaxis
Respiratory Burst Involved In Defense Response
Protein Phosphorylation
Inflammatory Response
Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
T Cell Chemotaxis
Phosphatidylinositol 3-kinase Signaling
Phosphorylation
Cell Migration
Natural Killer Cell Activation
T Cell Differentiation
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Neutrophil Apoptotic Process
Natural Killer Cell Chemotaxis
B Cell Chemotaxis
Phosphatidylinositol-3-phosphate Biosynthetic Process
Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway
T Cell Activation
B Cell Activation
Mast Cell Degranulation
Innate Immune Response
Positive Regulation Of Angiogenesis
Phosphatidylinositol Phosphate Biosynthetic Process
Phosphatidylinositol-mediated Signaling
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of Protein Kinase B Signaling
Mast Cell Differentiation
Neutrophil Extravasation
Positive Regulation Of Epithelial Tube Formation
Pathways
PIP3 activates AKT signaling
Synthesis of PIPs at the plasma membrane
Constitutive Signaling by Aberrant PI3K in Cancer
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Caffeine
XL765
TG100-115
2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE
Idelalisib
Duvelisib
Fostamatinib
Copanlisib
Diseases
GWAS
Diisocyanate-induced asthma (
25918132
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Irritable bowel syndrome (
29626450
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
27863252
)
Systemising (
31508503
)
Testicular germ cell tumor (
28604728
)
Interacting Genes
2 interacting genes:
EEF1G
PIK3CD
16 interacting genes:
ASCC2
ERAS
HRAS
IL3
IL4
IRS2
KITLG
MCRIP2
MTOR
PIK3CG
PIK3R1
PIK3R2
PIK3R3
RALY
TAGLN
TNPO2
Entrez ID
84331
5293
HPRD ID
17503
04161
Ensembl ID
ENSG00000172366
ENSG00000171608
Uniprot IDs
Q9BUT9
A0A2K8FKV1
O00329
PDB IDs
5DXU
5M6U
5T8F
5UBT
5VLR
6G6W
6OCO
6OCU
6PYR
6PYU
7JIS
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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