PIK3CD and ERAS

Number of citations of the paper that reports this interaction (PubMedID 12774123)
112

Data Source:
HPRD (in vivo)

		PIK3CD	ERAS
Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	ES cell expressed Ras
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Membrane	Plasma Membrane
	Molecular Function	Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Natural Killer Cell Differentiation Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Inflammatory Response Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Phosphatidylinositol 3-kinase Signaling Phosphorylation Cell Migration Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Neutrophil Apoptotic Process Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Innate Immune Response Positive Regulation Of Angiogenesis Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Mast Cell Differentiation Neutrophil Extravasation Positive Regulation Of Epithelial Tube Formation	Ras Protein Signal Transduction
Pathways		PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Caffeine XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE Idelalisib Duvelisib Fostamatinib Copanlisib
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Irritable bowel syndrome ( 29626450) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Systemising ( 31508503) Testicular germ cell tumor ( 28604728)
Interacting Genes		16 interacting genes: ASCC2 ERAS HRAS IL3 IL4 IRS2 KITLG MCRIP2 MTOR PIK3CG PIK3R1 PIK3R2 PIK3R3 RALY TAGLN TNPO2	4 interacting genes: MYO15B PIK3CD PIK3R1 TLX3
Entrez ID		5293	3266
HPRD ID		04161	02339
Ensembl ID		ENSG00000171608	ENSG00000187682
Uniprot IDs		A0A2K8FKV1 O00329	Q7Z444
PDB IDs		5DXU 5M6U 5T8F 5UBT 5VLR 6G6W 6OCO 6OCU 6PYR 6PYU 7JIS
Enriched GO Terms of Interacting Partners?
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