CASP8 and MAPK1

Number of citations of the paper that reports this interaction (PubMedID 17290218)
13

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CASP8	MAPK1
Description		caspase 8	mitogen-activated protein kinase 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Protein-containing Complex Neuron Projection Cell Body Membrane Raft Ripoptosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Lumen Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Caveola Focal Adhesion Postsynaptic Density Axon Pseudopodium Dendrite Cytoplasm Protein-containing Complex Azurophil Granule Lumen Perikaryon Mitotic Spindle Ficolin-1-rich Granule Lumen
	Molecular Function	Cysteine-type Endopeptidase Activity Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Scaffold Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Phosphotyrosine Residue Binding Double-stranded DNA Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Phosphatase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Angiogenesis Regulation Of Cytokine Production Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Heart Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Cold Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Natural Killer Cell Activation Macrophage Differentiation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Response To Tumor Necrosis Factor TRAIL-activated Apoptotic Signaling Pathway T Cell Activation B Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Response To Antibiotic Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Necroptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Pyroptosis Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Self Proteolysis Positive Regulation Of Neuron Death	Protein Phosphorylation Apoptotic Process Chemotaxis Cellular Response To DNA Damage Stimulus Cell Cycle Signal Transduction Cell Surface Receptor Signaling Pathway Chemical Synaptic Transmission Aging Learning Or Memory Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Peptidyl-threonine Phosphorylation Diadenosine Tetraphosphate Biosynthetic Process Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cytosine Metabolic Process Regulation Of Ossification Regulation Of Cellular PH Thyroid Gland Development Regulation Of Protein Stability Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Stress-activated MAPK Cascade Mammary Gland Epithelial Cell Proliferation Cellular Response To Amino Acid Starvation Cellular Response To Reactive Oxygen Species Response To Nicotine Intracellular Signal Transduction ERBB Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Outer Ear Morphogenesis Response To Exogenous DsRNA Response To Estrogen Negative Regulation Of Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Decidualization Thymus Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization Positive Regulation Of Telomerase Activity Bergmann Glial Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Long-term Synaptic Potentiation Face Development Lung Morphogenesis Trachea Formation Labyrinthine Layer Blood Vessel Development Cardiac Neural Crest Cell Development Involved In Heart Development ERK1 And ERK2 Cascade Response To Epidermal Growth Factor Cellular Response To Cadmium Ion Cellular Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Macrophage Proliferation Cellular Response To Dopamine Positive Regulation Of Telomere Capping Regulation Of Early Endosome To Late Endosome Transport
Pathways		Apoptotic cleavage of cellular proteins Caspase activation via Death Receptors in the presence of ligand NOD1/2 Signaling Pathway TRIF-mediated programmed cell death Caspase-mediated cleavage of cytoskeletal proteins Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling CLEC7A/inflammasome pathway Regulation of necroptotic cell death Dimerization of procaspase-8 Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Microbial modulation of RIPK1-mediated regulated necrosis Defective RIPK1-mediated regulated necrosis	phospho-PLA2 pathway RAF-independent MAPK1/3 activation MAPK1 (ERK2) activation Spry regulation of FGF signaling Golgi Cisternae Pericentriolar Stack Reorganization Frs2-mediated activation ERK/MAPK targets ERK/MAPK targets ERKs are inactivated Regulation of actin dynamics for phagocytic cup formation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Oncogene Induced Senescence FCERI mediated MAPK activation Regulation of HSF1-mediated heat shock response NCAM signaling for neurite out-growth Recycling pathway of L1 RSK activation Signal transduction by L1 Activation of the AP-1 family of transcription factors Thrombin signalling through proteinase activated receptors (PARs) Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate NADPH Oxidases RAF/MAP kinase cascade MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signal attenuation Advanced glycosylation endproduct receptor signaling Gastrin-CREB signalling pathway via PKC and MAPK ESR-mediated signaling RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Regulation of the apoptosome activity Estrogen-stimulated signaling through PRKCZ Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Suppression of apoptosis Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by MAPK mutants Signaling by RAF1 mutants FCGR3A-mediated phagocytosis Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling
Drugs		Bryostatin 1 Bardoxolone	Acetylsalicylic acid Minocycline Isoprenaline Arsenic trioxide Olomoucine Phosphonothreonine Purvalanol SB220025 Seliciclib Perifosine N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine Turpentine Ulixertinib
Diseases
GWAS		Basal cell carcinoma ( 33549134 28177523 25855136) Breast cancer ( 29059683) Chronic lymphocytic leukemia ( 28165464 26956414 23770605) Cutaneous malignant melanoma ( 32341527) Esophageal squamous cell carcinoma ( 25129146) Lymphocyte counts ( 27863252) Melanoma ( 21983787 28212542) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Nevus count or cutaneous melanoma ( 32341527 30429480) Non-small cell lung cancer ( 31326317) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Rheumatoid arthritis ( 30423114 24390342) Spleen volume ( 34128465) White blood cell count ( 32888494)	Bipolar disorder ( 31043756) Body size at age 10 ( 32376654) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 31604244 24076602 21833088) Serum interleukin-6 concentration in active individuals ( 32928877) Superior parietal cortex volume ( 31530798)
Interacting Genes		140 interacting genes: AGR3 ANGPTL4 AP1M1 APAF1 APP AR ATAD2 ATG4D ATP1A3 BAP1 BCAP31 BCL2 BCL2L1 BCL2L10 BEX1 BFAR BID BIRC6 BLID BMPR2 BRD1 CASC3 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8AP2 CASP9 CCNL1 CDH1 CDH13 CDK11B CDKN1B CFLAR CHD3 CHUK CNBP COPS6 CRADD CTNNB1 DDX5 DEDD DEDD2 EDA2R EIF2AK2 EPSTI1 ERBB4 ERRFI1 FADD FAF1 FAS FYN GLCE GMEB1 GREB1 GRIA1 GZMB HBP1 HDAC7 HECTD3 HIP1 IFT57 IKBKB IKBKG IL13RA2 IL24 ILK KLK5 KLK9 KRT18 LYPD3 MAP1LC3B MAP3K14 MAP4K4 MAPK1 MAPK3 MAPT NOD1 NOL3 NR1H4 NSD3 OGT PARK7 PARP1 PARP2 PCYT1A PDIA6 PEA15 PIAS1 PICALM PIK3C3 PLA2G4B PLEC PLIN4 PRDM14 PRDX6 PRKCI PRKCZ PRKN PRRX2 PRSS50 PSEN1 PSEN2 PSMC3IP QDPR RALBP1 RB1 RIPK1 RIPK2 RNF31 RYBP S100A14 SCGB2A2 SERPINB5 SNRPD3 SNX19 SOX2 SRC SRF ST14 STK24 SUMO1 TFCP2 TNFRSF10A TNFRSF10B TOPORS TRAF1 TRAF2 TRAF6 UBC UMPS USO1 VIM VPS45 YBX1 ZNF707	251 interacting genes: AR ARRB1 ARRB2 ATF2 ATP1A1 BANP BCL2 BCL3 BCL6 BRAF C1QBP CACYBP CAD CALCOCO1 CAPN2 CASP8 CASP9 CAV1 CD19 CDC25C CDX2 CEBPB CEP55 CHN1 CITED2 CMTM3 COPS6 CREBBP CRP CSNK2A1 CTNND1 CTSD CUEDC2 DAPK1 DUSP1 DUSP16 DUSP2 DUSP3 DUSP4 DUSP5 DUSP6 DUSP7 DUSP9 DYRK1B EGFR EGLN3 EIF4EBP1 ELK1 ELK4 ENAH EP300 EPOR ERF ESR1 ESR2 ETS1 FCGR2B FHL3 FOS FOXO3 FRS2 FRS3 GAB1 GAB2 GABRR1 GAPDH GATA1 GATA2 GATA4 GJA1 GMFB GNPTAB GORASP2 GRB10 GRB2 GSK3B HDAC4 HDAC6 HIF1A HNF4A HOMEZ HSF1 HSF4 HSP90AA1 ID2 IER3 IFI35 IFNAR1 ILF3 IQGAP1 IRS1 ITGB6 JUN JUND KARS1 KDR KHDRBS1 KLF11 KRT8 KSR1 KSR2 LAMTOR3 LCK LIFR LIPE LRPAP1 LRRC4 LZTS2 MAFA MAP2K1 MAP2K2 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K10 MAPK14 MAPK8 MAPKAPK5 MAPT MBP MCL1 MDFI METAP2 METTL3 MITF MKNK1 MKNK2 MSX2 MTIF3 MTPN MYB MYC NCOA1 NCOA3 NDE1 NEFH NEK2 NGFR NKX2-1 NOXA1 NR3C1 NR4A1 NR4A2 NR5A1 NRL NTRK3 NUP153 PAK1 PAK2 PAX5 PDE4D PEA15 PEBP1 PKM PLA2G4A PLAGL2 PLAT PLCB1 PLK3 POLR2G PPARA PPARG PPP1CA PPP1R18 PPP1R9B PPP2CA PPP2R5B PPP2R5C PRDX6 PRKCD PRKCE PRKCZ PRPSAP1 PSMA1 PTPDC1 PTPN1 PTPN5 PTPN7 PTPRC PTPRE PTPRH PTPRR PXN RAF1 RB1 REST RET RGS19 RNF216 RNF8 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RUNX1 RXRA SCNN1G SH2D3C SHANK3 SHC1 SLC9A1 SMAD1 SMAD2 SMAD3 SMAD4 SNCA SNCG SORBS3 SOS1 SOX10 SP1 SREBF1 SREBF2 STAT3 STAT5A STAT5B STXBP1 STYX SUPT20H TCF3 TFCP2 TGIF1 TH TIAL1 TLE5 TNFRSF1A TNFRSF25 TNFSF11 TNIP1 TNIP2 TNKS2 TOB1 TOP2A TP53 TPR TSC2 TTN TXNIP UBE3A UBR5 UBTF VAV1 VDR YBX1 YBX3 ZBTB42 ZC3HC1 ZFP36
Entrez ID		841	5594
HPRD ID		03459	01496
Ensembl ID		ENSG00000064012	ENSG00000100030
Uniprot IDs		A0A024R3Z8 Q14790	P28482 Q1HBJ4 Q499G7
PDB IDs		1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 2K7Z 2Y1L 3H11 3KJN 3KJQ 4JJ7 4PRZ 4PS1 4ZBW 5H31 5H33 5JQE 5L08 6AGW 6PX9	1PME 1TVO 1WZY 2OJG 2OJI 2OJJ 2Y9Q 3D42 3D44 3I5Z 3I60 3SA0 3TEI 3W55 4FMQ 4FUX 4FUY 4FV0 4FV1 4FV2 4FV3 4FV4 4FV5 4FV6 4FV7 4FV8 4FV9 4G6N 4G6O 4H3P 4H3Q 4IZ5 4IZ7 4IZA 4N0S 4NIF 4O6E 4QP1 4QP2 4QP3 4QP4 4QP6 4QP7 4QP8 4QP9 4QPA 4QTA 4QTE 4XJ0 4ZXT 4ZZM 4ZZN 4ZZO 5AX3 5BUE 5BUI 5BUJ 5BVD 5BVE 5BVF 5K4I 5LCJ 5LCK 5NGU 5NHF 5NHH 5NHJ 5NHL 5NHO 5NHP 5NHV 5V60 5V61 5V62 5WP1 6D5Y 6DMG 6G54 6G8X 6G91 6G92 6G93 6G97 6G9A 6G9D 6G9H 6G9J 6G9K 6G9M 6G9N 6GDM 6GDQ 6GE0 6GJB 6GJD 6NBS 6OPG 6OPH 6OPI 6Q7K 6Q7S 6Q7T 6QA1 6QA3 6QA4 6QAG 6QAH 6QAL 6QAQ 6QAW 6RQ4 6SLG
Enriched GO Terms of Interacting Partners?
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