AXIN2 and CAPN7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		AXIN2	CAPN7
Description		axin 2	calpain 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Beta-catenin Destruction Complex	Nucleus Centrosome Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Beta-catenin Binding Enzyme Binding Ubiquitin Protein Ligase Binding I-SMAD Binding	Endopeptidase Activity Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding MIT Domain Binding
	Biological Process	Somitogenesis Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Odontogenesis Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Canonical Wnt Signaling Pathway	Positive Regulation Of Epithelial Cell Migration Self Proteolysis
Pathways		TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases	Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Refractive error ( 32231278)	Metabolite levels ( 23823483)
Interacting Genes		56 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 FXR1 FXR2 GSK3A GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SLC9A3R1 SMAD1 SMAD3 SMAD7 STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648	19 interacting genes: ARNT2 AXIN2 CEP63 CTBP2 GOLGA2 IFT88 IST1 MAD1L1 MAGED1 MDM4 PPP1R13B PRPSAP1 TNFAIP1 TRIM27 UBL7 VHL ZBTB9 ZFYVE19 ZNF655
Entrez ID		8313	23473
HPRD ID		04935	05908
Ensembl ID		ENSG00000168646	ENSG00000131375
Uniprot IDs		E7ES00 Q9Y2T1	Q7Z479 Q9Y6W3
PDB IDs			2QFE
Enriched GO Terms of Interacting Partners?
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