AXIN2 and MCRS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		AXIN2	MCRS1
Description		axin 2	microspherule protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Beta-catenin Destruction Complex	Histone Acetyltransferase Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Polysome Dendrite Ino80 Complex Perikaryon NSL Complex MLL1 Complex
	Molecular Function	Protein Binding Beta-catenin Binding Enzyme Binding Ubiquitin Protein Ligase Binding I-SMAD Binding	G-quadruplex RNA Binding Protein Binding Poly(U) RNA Binding Poly(G) Binding
	Biological Process	Somitogenesis Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Odontogenesis Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Canonical Wnt Signaling Pathway	DNA Repair DNA Recombination Cellular Protein Modification Process Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Localization To Nucleolus
Pathways		TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases	HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Refractive error ( 32231278)
Interacting Genes		56 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 FXR1 FXR2 GSK3A GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SLC9A3R1 SMAD1 SMAD3 SMAD7 STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648	128 interacting genes: AGGF1 AXIN2 BACH2 BEND3 BHLHA9 BHLHE40 BLM BRD8 BRMS1 BRMS1L C18orf25 C2CD6 C7orf57 C8orf34 CARD9 CAVIN2 CBY2 CCDC13 CCDC136 CCDC85B CCHCR1 CCNH CDCA7L CEP44 CEP70 CNTROB COIL CREB3L3 CSRNP1 CYSRT1 CYTIP DAXX DDN DRAP1 DVL2 EGR2 ERF EVI5 FAM9A FNDC8 FSD2 FXR1 FXR2 GAS7 GCC1 GEM GIGYF1 GOLGA2 GPBP1 HMBOX1 HOOK2 IKZF1 IKZF3 IKZF4 INO80E INSYN1 JAKMIP1 KANK2 KAT7 KDM1A KIAA1958 KRT35 KRTAP10-7 KRTAP2-3 KRTAP2-4 KXD1 LIG4 LSM6 LZTS1 MAGEA11 MAGEA6 MAPK9 MED4 MEOX1 MFAP1 MIER2 MIER3 NAA10 NAB2 NKAPD1 NOP2 OSBPL3 PBK PBX2 PCM1 PHC2 PIBF1 PINX1 PKNOX2 PPP1R13B PRMT5 PSTPIP1 PTEN RABEP1 RALYL RARA RETREG3 RIPPLY3 SH2B2 SHANK3 SNAPC5 SP4 SRRM4 SSMEM1 SUV39H1 TADA2B TBC1D1 TERT TFAP4 TLE5 TNIP1 TNNI1 TP63 TRIM37 TRIM41 TSPYL2 UPF3B USHBP1 WASHC3 WBP11 XIAP ZBTB22 ZCCHC10 ZCCHC12 ZNF23 ZNF639 ZNF8 ZRANB1
Entrez ID		8313	10445
HPRD ID		04935	11298
Ensembl ID		ENSG00000168646	ENSG00000187778
Uniprot IDs		E7ES00 Q9Y2T1	A0A024R134 Q96EZ8
PDB IDs
Enriched GO Terms of Interacting Partners?
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