DGCR6 and RFX6

Number of citations of the paper that reports this interaction (PubMedID 24722188)
63

Data Source:
BioGRID (two hybrid)

		DGCR6	RFX6
Description		DiGeorge syndrome critical region gene 6	regulatory factor X6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Extracellular Matrix	Chromatin Nucleus
	Molecular Function	Molecular_function Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Cell Adhesion Animal Organ Morphogenesis	Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Regulation Of Transcription By RNA Polymerase II Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation
Pathways			Regulation of gene expression in beta cells
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Metabolite levels ( 23823483) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)	Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease ( 30804561) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 27841878) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fasting glucose ( 34059833) Height ( 31562340) Inflammatory bowel disease ( 27569725) Lung cancer ( 28604730) Neutrophil percentage of granulocytes ( 27863252) Offspring birth weight ( 31043758) Prostate cancer ( 20676098 31562322 26443449) Serum total protein level ( 29403010) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		66 interacting genes: ADAMTSL4 AGTRAP AKAP8L APP ARNT2 C1orf94 C3orf62 CBLL1 CBY2 CCDC33 CEP126 CTBP1 DEUP1 DLGAP2 DLX2 DNPEP DOCK8 EFEMP2 EFHC2 ENKD1 ESS2 FBF1 FH GOLGA2 GSE1 HGS HOMEZ IHO1 IKZF3 INIP KLHL12 KRTAP12-2 LZTS2 MBIP MEIS2 MEOX2 MIA2 MID2 MIPOL1 NAB2 NECAB2 NOTCH2NLA NQO2 NUP54 NUP62 PDLIM7 PRDM14 RABGEF1 REL RFX6 RIMBP3 SPRY2 SS18L1 TCF12 TCF4 TFIP11 TLE5 TRAF1 TRAF2 TRIM27 TUBGCP4 VCP ZBED1 ZC4H2 ZNF398 ZNF446	41 interacting genes: AGXT ARNT2 CATSPER1 CCNK CSTF2 CYFIP1 DGCR6 DMRT3 DTX2 DUSP21 ESR2 FHL3 FRS3 HGS KCTD9 KIF1A LGALS4 LMO3 MEMO1 NEDD9 PATZ1 PITX1 PLEKHN1 PPP1R32 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 TEKT3 TEKT4 TENT5B TLE5 USP2 VPS37C ZMYND19 ZNF688
Entrez ID		8214	222546
HPRD ID		03177	11490
Ensembl ID		ENSG00000183628	ENSG00000185002
Uniprot IDs		Q14129 X5D7D2	Q8HWS3
PDB IDs
Enriched GO Terms of Interacting Partners?
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